Lentiviral Vector Design and Imaging Approaches to Visualize the Early Stages of Cellular Reprogramming

Article, Other literature type English OPEN
Warlich, Eva; Kuehle, Johannes; Cantz, Tobias; Brugman, Martijn H; Maetzig, Tobias; Galla, Melanie; Filipczyk, Adam A; Halle, Stephan; Klump, Hannes; Schöler, Hans R; Baum, Christopher; Schroeder, Timm; Schambach, Axel;
  • Publisher: Elsevier BV
  • Journal: Molecular Therapy,volume 19,issue 4,pages782-789 (issn: 1525-0016)
  • Related identifiers: doi: 10.1038/mt.2010.314, pmc: PMC3070104
  • Subject: Molecular Biology | Original Article | Genetics | Drug Discovery | Pharmacology | Molecular Medicine

Induced pluripotent stem cells (iPSCs) can be derived from somatic cells by gene transfer of reprogramming transcription factors. Expression levels of these factors strongly influence the overall efficacy to form iPSC colonies, but additional contribution of stochastic ... View more
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