Assessing the Association between Natural Food Folate Intake and Blood Folate Concentrations: A Systematic Review and Bayesian Meta-Analysis of Trials and Observational Studies

Other literature type, Article English OPEN
Marchetta, Claire ; Devine, Owen ; Crider, Krista ; Tsang, Becky ; Cordero, Amy ; Qi, Yan ; Guo, Jing ; Berry, Robert ; Rosenthal, Jorge ; Mulinare, Joseph ; Mersereau, Patricia ; Hamner, Heather (2015)
  • Publisher: Multidisciplinary Digital Publishing Institute
  • Journal: Nutrients, volume 7, issue 4, pages 2,663-2,686 (issn: 2072-6643, eissn: 2072-6643)
  • Related identifiers: pmc: PMC4425166, doi: 10.3390/nu7042663
  • Subject: Nutrition. Foods and food supply | TX341-641 | RBC folate | serum/plasma folate | food folate | Article

Folate is found naturally in foods or as synthetic folic acid in dietary supplements and fortified foods. Adequate periconceptional folic acid intake can prevent neural tube defects. Folate intake impacts blood folate concentration; however, the dose-response between natural food folate and blood folate concentrations has not been well described. We estimated this association among healthy females. A systematic literature review identified studies (1 1992–3 2014) with both natural food folate intake alone and blood folate concentration among females aged 12–49 years. Bayesian methods were used to estimate regression model parameters describing the association between natural food folate intake and subsequent blood folate concentration. Seven controlled trials and 29 observational studies met the inclusion criteria. For the six studies using microbiologic assay (MA) included in the meta-analysis, we estimate that a 6% (95% Credible Interval (CrI): 4%, 9%) increase in red blood cell (RBC) folate concentration and a 7% (95% CrI: 1%, 12%) increase in serum/plasma folate concentration can occur for every 10% increase in natural food folate intake. Using modeled results, we estimate that a natural food folate intake of ≥450 μg dietary folate equivalents (DFE)/day could achieve the lower bound of an RBC folate concentration (~1050 nmol/L) associated with the lowest risk of a neural tube defect. Natural food folate intake affects blood folate concentration and adequate intakes could help women achieve a RBC folate concentration associated with a risk of 6 neural tube defects/10,000 live births.
  • References (80)
    80 references, page 1 of 8

    National Institutes of Health: Office of Dietary Supplements Folate. Available online: http://ods.od.nih.gov/factsheets/Folate-HealthProfessional/ (accessed on 4 September 2014).

    Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline; National Academy Press: Washington, DC, USA, 1998.

    Gibson, R.S. Principles of Nutritional Assessment, 2nd ed.; Oxford University Press: New York, NY, USA, 2005.

    World Health Organization. Serum and Red Blood Cell Folate Concentrations for Assessing Folate Status in Populations; World Health Organization: Geneva, Switzerland, 2013.

    5. Daly, L.E.; Kirke, P.N.; Molloy, A.; Weir, D.G.; Scott, J.M. Folate levels and neural tube defects: Implications for prevention. JAMA 1995, 274, 1698-1702.

    6. Crider, K.S.; Devine, O.; Hao, L.; Dowling, N.F.; Li, S.; Molloy, A.M.; Li, Z.; Zhu, J.-H.; Berry, R.J. Population red blood cell folate concentrations for prevention of neural tube defects: Bayesian model. BMJ 2014, 349, g4554, doi:10.1136/bmj.g4554.

    7. Pfeiffer, C.; Hughes, J.P.; Lacher, D.A.; Bailey, R.L.; Berry, R.J.; Zhang, M.; Yetley, E.A.; Rader, J.I.; Sempos, C.T.; Johnson, C.L. Estimation of trends in serum and RBC folate in the U.S. population from pre- to postfortification using assay-adjusted data from the NHANES 1988-2010. J. Nutr. 2012, 142, 886-893.

    8. Crider, K.S.; Zhu, J.-H.; Hao, L.; Yang, Q.-H.; Yang, T.P.; Gindler, J.; Maneval, D.R.; Quinlivan, E.P.; Li, Z.; Bailey, L.B.; et al. MTHFR 677→T genotype is associated with folate and homocysteine concentrations in a large, population-based, double-blind trial of folic acid supplementation. Am. J. Clin. Nutr. 2011, 93, 1365-1372.

    9. Berry, R.J.; Li, Z.; Erickson, J.D.; Li, S.; Moore, C.A.; Wang, H.; Mulinare, J.; Zhao, P.; Wong, L.Y.; Gindler, J.; et al. Prevention of neural-tube defects with folic acid in China. China-U.S. collaborative project for neural tube defect prevention. N. Engl. J. Med. 1999, 341, 1485-1490.

    10. Centers for Disease Control and Prevention. Recommendations for the use of folic acid to reduce the number of cases of spina bifida and other neural tube defects. MMWR Recomm. Rep. 1992, 41, 1-7.

  • Related Research Results (1)
  • Metrics
    No metrics available
Share - Bookmark