DNA mismatch repair deficiency in sporadic colorectal cancer and Lynch Syndrome

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Poulogiannis , George ; Frayling , Ian ; Arends , Mark (2009)
  • Publisher: Wiley
  • Related identifiers: doi: 10.1111/j.1365-2559.2009.03392.x
  • Subject: Medicine
    mesheuropmc: congenital, hereditary, and neonatal diseases and abnormalities | digestive system diseases | neoplasms

International audience; DNA mismatch repair (MMR) deficiency is one of the best understood forms of genetic instability in colorectal cancer (CRC), and is characterised by the loss of function of the MMR pathway. Failure to repair replication-associated errors due to a ... View more
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