The guinea pig ileum lacks the direct, high-potency, M2-muscarinic, contractile mechanism characteristic of the mouse ileum

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Griffin, Michael T. ; Matsui, Minoru ; Ostrom, Rennolds S. ; Ehlert, Frederick J. (2009)
  • Publisher: Springer Nature
  • Journal: Naunyn-Schmiedeberg's Archives of Pharmacology, volume 380, issue 4, pages 327-335 (issn: 0028-1298, eissn: 1432-1912)
  • Related identifiers: pmc: PMC2749929, doi: 10.1007/s00210-009-0434-8
  • Subject: Ileum | Original Article | Guinea pig | Neurosciences | M3 muscarinic receptor | Muscarinic receptor knockout mice | 4-DAMP mustard | Pharmacology | Biomedicine | Pharmacology/Toxicology | M2 muscarinic receptor

We explored whether the M2 muscarinic receptor in the guinea pig ileum elicits a highly potent, direct-contractile response, like that from the M3 muscarinic receptor knockout mouse. First, we characterized the irreversible receptor-blocking activity of 4-DAMP mustard i... View more
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