The guinea pig ileum lacks the direct, high-potency, M2- muscarinic, contractile mechanism characteristic of the mouse ileum

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Griffin, Michael T.; Matsui, Minoru; Ostrom, Rennolds S.; Ehlert, Frederick J.;
(2009)

We explored whether the M2 muscarinic receptor in the guinea pig ileum elicits a highly potent, direct-contractile response, like that from the M3 muscarinic receptor knockout mouse. First, we characterized the irreversible receptor-blocking activity of 4-DAMP mustard i... View more
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