The guinea pig ileum lacks the direct, high-potency, M2- muscarinic, contractile mechanism characteristic of the mouse ileum

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Griffin, Michael T.; Matsui, Minoru; Ostrom, Rennolds S.; Ehlert, Frederick J.;

(2009)

Publisher: eScholarship, University of California

Journal: volume 380,issue 4,pages327-335issn: 0028-1298, eissn: 1432-1912

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Related identifiers: pmc: PMC2749929, doi: 10.1007/s00210-009-0434-8
Subject: Ileum | Original Article | Guinea pig | Neurosciences | M3 muscarinic receptor | Muscarinic receptor knockout mice | 4-DAMP mustard | Pharmacology | Biomedicine | Pharmacology/Toxicology | M2 muscarinic receptor

We explored whether the M2 muscarinic receptor in the guinea pig ileum elicits a highly potent, direct-contractile response, like that from the M3 muscarinic receptor knockout mouse. First, we characterized the irreversible receptor-blocking activity of 4-DAMP mustard i... View more

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Chiba Institute of Science ( Chiba Institute of Science ) Japan Website url: http://www.cis.ac.jp/en/index.html	90%
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