SOS2 and ACP1 Loci Identified through Large-Scale Exome Chip Analysis Regulate Kidney Development and Function

Article, Other literature type English OPEN
Li, Man; Li, Yong; Weeks, Olivia; Mijatovic, Vladan; Teumer, Alexander; Huffman, Jennifer E; Tromp, Gerard; Fuchsberger, Christian; Gorski, Mathias; Lyytikäinen, Leo-Pekka; Nutile, Teresa; Sedaghat, Sanaz; Sorice, Rossella; Tin, Adrienne; Yang, Qiong; Ahluwalia, Tarunveer S; Arking, Dan E; Bihlmeyer, Nathan A; Böger, Carsten A; Carroll, Robert J; Chasman, Daniel I; Cornelis, Marilyn C; Dehghan, Abbas; Faul, Jessica D; Feitosa, Mary F; Gambaro, Giovanni; Gasparini, Paolo; Giulianini, Franco; Heid, Iris; Huang, Jinyan; ... view all 50 authors
  • Publisher: American Society of Nephrology
  • Journal: volume 28,issue 3,pages981-994issn: 1046-6673, eissn: 1533-3450
  • Publisher copyright policies & self-archiving
  • Related identifiers: pmc: PMC5328154, doi: 10.1681/ASN.2016020131
  • Subject: human genetics | Glomerular Filtration Rate | Meta-Analysis | Proto-Oncogene Proteins | Genetic Loci | Protein Tyrosine Phosphatases | Kidney | Exome | kidney development | Clinical Research | Genome-Wide Association Study | Son of Sevenless Proteins | renal function | Journal Article | Animals | Zebrafish | Humans

<p>Genome-wide association studies have identified &gt;50 common variants associated with kidney function, but these variants do not fully explain the variation in eGFR. We performed a two-stage meta-analysis of associations between genotypes from the Illumina exome arr... View more