A Mitochondrial Power Play in Lymphoma

Article, Other literature type English OPEN
DeBerardinis, Ralph J. (2012)
  • Publisher: Elsevier BV
  • Journal: Cancer Cell, volume 22, issue 4, pages 423-424 (issn: 1535-6108)
  • Related identifiers: doi: 10.1016/j.ccr.2012.09.023
  • Subject: Cell Biology | Article | Cancer Research | Oncology

Deregulated energetics is a hallmark of malignancy, but metabolic heterogeneity among individual tumors is unknown. A study by Caro et al. in this issue of Cancer Cell demonstrates that a subset of lymphomas is defined by reliance on mitochondrial energy generation and is selectively killed when this pathway is impaired.
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