Cosmosiin Increases ADAM10 Expression via Mechanisms Involving 5’UTR and PI3K Signaling

Article English OPEN
Zhuo Min ; Ying Tang ; Xiao-Tong Hu ; Bing-Lin Zhu ; Yuan-Lin Ma ; Jing-Si Zha ; Xiao-Juan Deng ; Zhen Yan ; Guo-Jun Chen (2018)
  • Publisher: Frontiers Media S.A.
  • Journal: Frontiers in Molecular Neuroscience, volume 11 (issn: 1662-5099, eissn: 1662-5099)
  • Related identifiers: doi: 10.3389/fnmol.2018.00198, doi: 10.3389/fnmol.2018.00198/full, pmc: PMC6004422
  • Subject: Neurosciences. Biological psychiatry. Neuropsychiatry | PI3K | Neuroscience | RC321-571 | translation | Original Research | ADAM10 | cosmosiin | 5’UTR

The α-secretase “a disintegrin and metalloproteinase domain-containing protein” (ADAM10) is involved in the processing of amyloid precursor protein (APP). Upregulation of ADAM10 precludes the generation of neurotoxic β-amyloid protein (Aβ) and represents a plausible the... View more
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