Crystal structure of equine serum albumin in complex with cetirizine reveals a novel drug binding site

Article, Other literature type English OPEN
Handing, Katarzyna B.; Shabalin, Ivan G.; Szlachta, Karol; Majorek, Karolina A.; Minor, Wladek;
(2016)

Serum albumin (SA) is the main transporter of drugs in mammalian blood plasma. Here, we report the first crystal structure of equine serum albumin (ESA) in complex with antihistamine drug cetirizine at a resolution of 2.1 Å. Cetirizine is bound in two sites – a novel dr... View more
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