Rho-associated kinase (ROCK) function is essential for cell cycle progression, senescence and tumorigenesis

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Kümper, Sandra; Mardakheh, Faraz K; McCarthy, Afshan; Yeo, Maggie; Stamp, Gordon W; Paul, Angela; Worboys, Jonathan; Sadok, Amine; Jørgensen, Claus; Guichard, Sabrina; Marshall, Christopher J;
  • Publisher: eLife Sciences Publications, Ltd
  • Journal: volume 5eissn: 2050-084X
  • Publisher copyright policies & self-archiving
  • Related identifiers: doi: 10.7554/eLife.12203, pmc: PMC4798951
  • Subject: Gene Knockout Techniques | Research Article | Cell Proliferation | Carcinoma, Non-Small-Cell Lung | Melanoma | rho-Associated Kinases | Mice | Research Support, Non-U.S. Gov't | actomyosin contractility | ROCK | actin cytoskeleton | Mouse | Cell Biology | cellular senescence | Carcinogenesis | rho kinase | Cancer Biology | Journal Article | Animals

eLife digest Animal cells contain a structure called the cytoskeleton, which helps give the cells their shape. This structure can rapidly disassemble and reassemble, which enables cells to change their shape, move and divide into two. Many proteins are involved in contr... View more