Microarchitecture, but Not Bone Mechanical Properties, Is Rescued with Growth Hormone Treatment in a Mouse Model of Growth Hormone Deficiency

Article English OPEN
Kristensen, Erika; Hallgrímsson, Benedikt; Morck, Douglas W.; Boyd, Steven K.;

Growth hormone (GH) deficiency is related to an increased fracture risk although it is not clear if this is due to compromised bone quality or a small bone size. We investigated the relationship between bone macrostructure, microarchitecture and mechanical properties in... View more
  • References (45)
    45 references, page 1 of 5

    Shore, R. M., Chesney, R. W., Mazess, R. B.. Bone mineral status in growth hormone deficiency. Journal of Pediatrics. 1980; 96 (3): 393-396

    Ross, J., Czernichow, P., Biller, B. M. K., Colao, A., Reiter, E., Kiess, W.. Growth hormone: health considerations beyond height gain. Pediatrics. 2010; 125 (4): e906-e918

    Monson, J. P., Drake, W. M., Carroll, P. V., Weaver, J. U., Rodriguez-Arnao, J., Savage, M. O.. Influence of growth hormone on accretion of bone mass. Hormone Research. 2002; 58, supplement 1: 52-56

    Högler, W., Shaw, N.. Childhood growth hormone deficiency, bone density, structures and fractures: scrutinizing the evidence. Clinical Endocrinology. 2010; 72 (3): 281-289

    Wüster, C., Abs, R., Bengtsson, B. A., Bennmarker, H., Feldt-Rasmussen, U., Hernberg-Ståhl, E., Monson, J. P., Westberg, B., Wilton, P.. The influence of growth hormone deficiency, growth hormone replacement therapy, and other aspects of hypopituitarism on fracture rate and bone mineral density. Journal of Bone and Mineral Research. 2001; 16 (2): 398-405

    Abs, R., Mattsson, A. F., Bengtsson, B. Å., Feldt-Rasmussen, U., Góth, M. I., Koltowska-Häggström, M., Monson, J. P., Verhelst, J., Wilton, P.. Isolated growth hormone (GH) deficiency in adult patients: baseline clinical characteristics and responses to GH replacement in comparison with hypopituitary patients: a sub-analysis of the KIMS database. Growth Hormone and IGF Research. 2005; 15 (5): 349-359

    Bouillon, R., Koledova, E., Bezlepkina, O., Nijs, J., Shavrikhova, E., Nagaeva, E., Chikulaeva, O., Peterkova, V., Dedov, I., Bakulin, A., Oganov, V., Attanasio, A. F.. Bone status and fracture prevalence in Russian adults with childhood-onset growth hormone deficiency. Journal of Clinical Endocrinology and Metabolism. 2004; 89 (10): 4993-4998

    Baroncelli, G. I., Bertelloni, S., Sodini, F., Saggese, G.. Acquisition of bone mass in normal individuals and in patients with growth hormone deficiency. Journal of Pediatric Endocrinology and Metabolism. 2003; 16, supplement 2: 327-335

    Mazziotti, G., Bianchi, A., Bonadonna, S., Nuzzo, M., Cimino, V., Fusco, A., de Marinis, L., Giustina, A.. Increased prevalence of radiological spinal deformities in adult patients with GH deficiency: influence of GH replacement therapy. Journal of Bone and Mineral Research. 2006; 21 (4): 520-528

    van der Sluis, I. M., Boot, A. M., Hop, W. C., de Rijke, Y. B., Krenning, E. P., de Muinck Keizer-Schrama, S. M. P. F.. Long-term effects of growth hormone therapy on bone mineral density, body composition, and serum lipid levels in growth hormone deficient children: a 6-year follow-up study. Hormone Research. 2002; 58 (5): 207-214

  • Related Organizations (5)
  • Metrics
Share - Bookmark