publication . Article . 2017

Methamphetamine induces Shati/Nat8L expression in the mouse nucleus accumbens via CREB- and dopamine D1 receptor-dependent mechanism.

Uno, Kyosuke; Miyazaki, Toh; Sodeyama, Kengo; Miyamoto, Yoshiaki; Nitta, Atsumi;
Open Access
  • Published: 01 Mar 2017 Journal: PLOS ONE, volume 12, page e0174196 (eissn: 1932-6203, Copyright policy)
  • Publisher: Public Library of Science (PLoS)
Shati/Nat8L significantly increased in the nucleus accumbens (NAc) of mice after repeated methamphetamine (METH) treatment. We reported that Shati/Nat8L overexpression in mouse NAc attenuated METH-induced hyperlocomotion, locomotor sensitization, and conditioned place preference. We recently found that Shati/Nat8L overexpression in NAc regulates the dopaminergic neuronal system via the activation of group II mGluRs by elevated N-acetylaspartylglutamate following N-acetylaspartate increase due to the overexpression. These findings suggest that Shati/Nat8L suppresses METH-induced responses. However, the mechanism by which METH increases the Shati/Nat8L mRNA expres...
free text keywords: Medicine, R, Science, Q, Research Article, Physical Sciences, Chemistry, Chemical Compounds, Organic Compounds, Amines, Catecholamines, Dopamine, Organic Chemistry, Biology and Life Sciences, Biochemistry, Neurochemistry, Neurotransmitters, Biogenic Amines, Neuroscience, Hormones, Research and Analysis Methods, Bioassays and Physiological Analysis, Biochemical Analysis, Enzyme Assays, Luciferase Assay, Genetics, DNA, Promoter Regions, Nucleic Acids, Gene Expression, Gene Regulation, Enzymology, Enzymes, Oxidoreductases, Luciferase, Proteins, Cell biology, Signal transduction, Cell signaling, CREB signaling, Anatomy, Brain, Nucleus Accumbens, Medicine and Health Sciences, Computational Biology, Genome Analysis, Chromatin Immunoprecipitation, Genomics, Neurochemicals, Dopaminergics
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