Antiangiogenic treatment diminishes renal injury and dysfunction via regulation of local AKT in early experimental diabetes.

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Bai, Xiaoyan; Li, Xiao; Tian, Jianwei; Zhou, Zhanmei;
(2014)
  • Publisher: Public Library of Science (PLoS)
  • Journal: PLoS ONE,volume 9,issue 4 (issn: 1932-6203, eissn: 1932-6203)
  • Publisher copyright policies & self-archiving
  • Related identifiers: doi: 10.1371/journal.pone.0096117, pmc: PMC3997561
  • Subject: Cancer Treatment | Signaling cascades | Chronic Kidney Disease | Animal Models | Research Article | Molecular Cell Biology | Diagnostic Medicine | Research Design | Antiangiogenesis Therapy | Pathology and Laboratory Medicine | AKT signaling cascade | Rodents | Oncology | Nephrology | Animals | Rats | Molecular Pathology | Animal Models of Disease | Biology and life sciences | Signal transduction | Research and Analysis Methods | Clinical Research Design | Medicine | Vertebrates | Developmental Nephrology | Q | R | Cell biology | Mammals | Model Organisms | Cell signaling | Science | Organisms | Medicine and Health Sciences | Diabetic Endocrinology | Endocrinology
    mesheuropmc: urologic and male genital diseases | urogenital system

In view of increased vascular endothelial growth factor-A (VEGF-A) expression and renal dysfunction in early diabetes, we designed a study to test whether VEGF-A inhibition can prevent early renal injury and dysfunction. We investigated the relationship and mechanism be... View more
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