Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease

Article, Other literature type English OPEN
Sabater-Lleal, Maria ; Huang, Jie ; Chasman, Daniel ; Naitza, Silvia ; Dehghan, Abbas ; Johnson, Andrew D. ; Teumer, Alexander ; Reiner, Alex P. ; Folkersen, Lasse ; Basu, Saonli ; Rudnicka, Alicja R. ; Trompet, Stella ; Malarstig, Anders ; Baumert, Jens ; Bis, Joshua C. ; Guo, Xiuqing ; Hottenga, Jouke J. ; Shin, So-Youn ; Lopez, Lorna M. ; Lahti, Jari ; Tanaka, Toshiko ; Yanek, Lisa R. ; Oudot-Mellakh, Tiphaine ; Wilson, James F. ; Navarro, Pau ; Huffman, Jennifer E. ; Zemunik, Tatijana ; Redline, Susan ; Mehra, Reena ; Pulanic, Drazen ... view all 55 authors (2013)
  • Publisher: LIPPINCOTT WILLIAMS & WILKINS
  • Journal: volume 128, issue 12, pages 1,310-1,324 (issn: 1524-4539)
  • Related identifiers: pmc: PMC3842025, doi: 10.1161/CIRCULATIONAHA.113.002251
  • Subject: fibrinogen | ARTERY-DISEASE | RISK-FACTORS | GENOTYPES | HEALTH | GENE-EXPRESSION | cardiovascular diseases | HEMOSTASIS | VARIANTS | Article | INDIVIDUAL PARTICIPANT METAANALYSIS | MYOCARDIAL-INFARCTION | genome-wide association study | CORONARY-HEART-DISEASE | gene expression

<p>Background Estimates of the heritability of plasma fibrinogen concentration, an established predictor of cardiovascular disease, range from 34% to 50%. Genetic variants so far identified by genome-wide association studies explain only a small proportion (&lt;2%) of i... View more
Share - Bookmark