Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease

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Sabater-Lleal, Maria; Huang, Jie; Chasman, Daniel; Naitza, Silvia; Dehghan, Abbas; Johnson, Andrew D.; Teumer, Alexander; Reiner, Alex P.; Folkersen, Lasse; Basu, Saonli; Rudnicka, Alicja R.; Trompet, Stella; Malarstig, Anders; Baumert, Jens; Bis, Joshua C.; Guo, Xiuqing; Hottenga, Jouke J.; Shin, So-Youn; Lopez, Lorna M.; Lahti, Jari; Tanaka, Toshiko; Yanek, Lisa R.; Oudot-Mellakh, Tiphaine; Wilson, James F.; Navarro, Pau; Huffman, Jennifer E.; Zemunik, Tatijana; Redline, Susan; Mehra, Reena; Pulanic, Drazen; ... view all 55 authors (2013)
  • Publisher: LIPPINCOTT WILLIAMS & WILKINS
  • Journal: volume 128,issue 12,pages1,310-1,324issn: 0009-7322
  • Related identifiers: doi: 10.1161/CIRCULATIONAHA.113.002251
  • Subject: fibrinogen | ARTERY-DISEASE | RISK-FACTORS | GENOTYPES | HEALTH | GENE-EXPRESSION | cardiovascular diseases | HEMOSTASIS | VARIANTS | INDIVIDUAL PARTICIPANT METAANALYSIS | MYOCARDIAL-INFARCTION | genome-wide association study | CORONARY-HEART-DISEASE | gene expression

<p>Background Estimates of the heritability of plasma fibrinogen concentration, an established predictor of cardiovascular disease, range from 34% to 50%. Genetic variants so far identified by genome-wide association studies explain only a small proportion (&lt;2%) of i... View more
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