Current Experience in Testing Mitochondrial Nutrients in Disorders Featuring Oxidative Stress and Mitochondrial Dysfunction: Rational Design of Chemoprevention Trials

Article, Review English OPEN
Pagano, Giovanni; Talamanca, Annarita Aiello; Castello, Giuseppe; Cordero, Mario D.; d'Ischia, Marco; Gadaleta, Maria Nicola; Pallardo, Federico V.; Petrović, Sandra; Tiano, Luca; Zatterale, Adriana;
(2014)
  • Publisher: MDPI AG
  • Journal: International Journal of Molecular Sciences, volume 15, issue 11, pages 20,169-20,208 (issn: 1422-0067, eissn: 1422-0067)
  • Publisher copyright policies & self-archiving
  • Related identifiers: doi: 10.3390/ijms151120169, pmc: PMC4264162
  • Subject: Chemistry | mitochondrial nutrients | Krebs cycle | Review | QD1-999 | mitochondrial dysfunction | oxidative stress | oxidative phosphorylation | Biology (General) | QH301-705.5

An extensive number of pathologies are associated with mitochondrial dysfunction (MDF) and oxidative stress (OS). Thus, mitochondrial cofactors termed “mitochondrial nutrients” (MN), such as α-lipoic acid (ALA), Coenzyme Q10 (CoQ10), and l-carnitine (CARN) (or its deriv... View more