ATM Induces Cell Death with Autophagy in Response to H2O2 Specifically in Caenorhabditis elegans Nondividing Cells

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Moriwaki, Takahito; Yamasaki, Akira; Zhang-Akiyama, Qiu-Mei;
(2018)
  • Publisher: Hindawi
  • Journal: Oxidative Medicine and Cellular Longevity,volume 2,018 (issn: 1942-0900, eissn: 1942-0994)
  • Related identifiers: pmc: PMC6051064, doi: 10.1155/2018/3862070
  • Subject: Research Article | Article Subject
    mesheuropmc: parasitic diseases

Introduction. Ataxia-telangiectasia-mutated (ATM) kinase is a master regulator of the DNA damage response and is directly activated by reactive oxygen species (ROSs) in addition to DNA double-stranded breaks. However, the physiological function of the response to ROSs i... View more
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