Unfolded protein response plays a critical role in heart damage after myocardial ischemia/reperfusion in rats

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Zhang, Chengcheng ; Tang, Yi ; Li, Yanming ; Xie, Liang ; Zhuang, Wei ; Liu, Jing ; Gong, Jianbin (2017)
  • Publisher: Public Library of Science
  • Journal: PLoS ONE, volume 12, issue 6 (issn: 1932-6203, eissn: 1932-6203)
  • Related identifiers: pmc: PMC5462470, doi: 10.1371/journal.pone.0179042
  • Subject: Signaling Cascades | Research Article | Anatomy | Transcription Factors | Cardiovascular Anatomy | Apoptosis | Secretory Pathway | Myocardium | Regulatory Proteins | Cell Processes | Genetics | Stress Signaling Cascade | Proteins | Reperfusion | DNA-binding proteins | Biology and Life Sciences | Cell Death | RNA | Signal Transduction | Medicine | Nucleic acids | Critical Care and Emergency Medicine | Heart | Q | R | Cell Biology | Cellular Structures and Organelles | Gene Regulation | Messenger RNA | Science | Biochemistry | Cell Signaling | Medicine and Health Sciences | Endoplasmic Reticulum | Gene Expression
    mesheuropmc: endocrine system | digestive system | biological phenomena, cell phenomena, and immunity | environment and public health | biological sciences

The unfolded protein response (UPR) plays a critical role in cell death mediated by ischemia/reperfusion (I/R) injury. However, little is known about the exact mechanism of UPR signaling pathways after myocardial I/R injury in rats. An attempt was therefore made to asse... View more
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