An erythroid specific nuclear factor binding to the proximal CACCC box of the beta-globin gene promoter

Article, Other literature type English OPEN
Mantovani, R; Malgaretti, N; Nicolis, S; Giglioni, B; Comi, P; Cappellini, N; Bertero, M T; Caligaris-Cappio, F; Ottolenghi, S;
(1988)
  • Publisher: Oxford University Press
  • Identifiers: pmc: PMC336631, doi: 10.1093/nar/16.10.4299
  • Subject: Genes ; Promoter Regions, Genetic ; Base Sequence ; Cell Line ; DNA Restriction Enzymes ; Erythroblasts ; Fetus ; Globins ; Humans ; Leukemia ; Lymphoma ; Nuclear Proteins | Settore BIO/18 - Genetica
    mesheuropmc: hemic and lymphatic diseases

We have used the gel retardation and DNAase I assays to investigate the binding of nuclear proteins to the human beta-globin promoter. Upon incubation with beta-globin promoter fragments containing the duplicated CACCC boxes, nuclear proteins from human erythroid cells ... View more
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