Liver-specific deletion of the Plpp3 gene alters plasma lipid composition and worsens atherosclerosis in apoE−/− mice

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Busnelli, Marco ; Manzini, Stefano ; Hilvo, Mika ; Parolini, Cinzia ; Ganzetti, Giulia S. ; Dellera, Federica ; Ekroos, Kim ; Jänis, Minna ; Escalante-Alcalde, Diana ; Sirtori, Cesare R. ; Laaksonen, Reijo ; Chiesa, Giulia (2017)
  • Publisher: Nature Publishing Group
  • Journal: Scientific Reports, volume 7 (issn: 2045-2322, eissn: 2045-2322)
  • Related identifiers: doi: 10.1038/srep44503, pmc: PMC5349609
  • Subject: Multidisciplinary | Settore BIO/14 - Farmacologia | Article

The PLPP3 gene encodes for a ubiquitous enzyme that dephosphorylates several lipid substrates. Genome-wide association studies identified PLPP3 as a gene that plays a role in coronary artery disease susceptibility. The aim of the study was to investigate the effect of P... View more