Opposing Tumor-Promoting and -Suppressive Functions of Rictor/mTORC2 Signaling in Adult Glioma and Pediatric SHH Medulloblastoma

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Seçkin Akgül; Yinghua Li; Siyuan Zheng; Marcel Kool; Daniel M. Treisman; Chaoyang Li; Yuan Wang; Susanne Gröbner; Tsuneo Ikenoue; Yiping Shen; Sandra Camelo-Piragua; Gerald Tomasek; Sebastian Stark; Vinay Guduguntla; James F. Gusella; Kun-Liang Guan; Stefan M. Pfister; Roel G.W. Verhaak; Yuan Zhu;

Summary: Most human cancers arise from stem and progenitor cells by the sequential accumulation of genetic and epigenetic alterations, while cancer modeling typically requires simultaneous multiple oncogenic events. Here, we show that a single p53 mutation, despite caus... View more
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