publication . Article . 2015

Hippocampal transcriptome-guided genetic analysis of correlated episodic memory phenotypes in Alzheimer's disease

Jingwen eYan; Jingwen eYan; Sungeun eKim; Sungeun eKim; Kwangsik eNho; Kwangsik eNho; Rui eChen; Rui eChen; Shannon L. Risacher; Shannon L. Risacher; ...
Open Access English
  • Published: 26 Mar 2015 Journal: Frontiers in Genetics, volume 6 (issn: 1664-8021, Copyright policy)
  • Publisher: Frontiers Media S.A.
Abstract
As the most common type of dementia, Alzheimer’s disease (AD) is a neurodegenerative disorder initially manifested by impaired memory performances. While the diagnosis information indicates a dichotomous status of a patient, memory scores have the potential to capture the continuous nature of the disease progression and may provide more insights into the underlying mechanism. In this work, we performed a targeted genetic study of memory scores on an AD cohort to identify the associations between a set of genes highly expressed in the hippocampal region and seven cognitive scores related to episodic memory. Both main effects and interaction effects of the targete...
Subjects
free text keywords: Genetics, genetic associate study, correlated phenotypes, hippocampus, episodic memory, Alzheimer's disease, Original Research, Alzheimer’s disease, QH426-470, Cognition, Genetic marker, Dementia, medicine.disease, medicine, Impaired memory, Biology, Bioinformatics, Disease, Apolipoprotein E
Funded by
NIH| Bioinformatics Strategies for Multidimensional Brain Imaging Genetics
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5R01LM011360-03
  • Funding stream: NATIONAL LIBRARY OF MEDICINE
,
NSF| III: Small: Collaborative Research: A Large-Scale Data Mining Framework for Genome-Wide Mapping of Multi-Modal Phenotypic Biomarkers and Outcome Prediction
Project
  • Funder: National Science Foundation (NSF)
  • Project Code: 1117335
  • Funding stream: Directorate for Computer & Information Science & Engineering | Division of Information and Intelligent Systems
,
NIH| Alzheimers Disease Neuroimaging Initiative
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 1U01AG024904-01
  • Funding stream: NATIONAL INSTITUTE ON AGING
,
NIH| Bioinformatics Strategies for Genome-Wide Association Studies
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5R01LM010098-08
  • Funding stream: NATIONAL LIBRARY OF MEDICINE
,
NIH| Amyloid Imaging, VMCI, and Analysis for ADNI
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 1RC2AG036535-01
  • Funding stream: NATIONAL INSTITUTE ON AGING
48 references, page 1 of 4

Backman L.Small B. J.Fratiglioni L. (2001). Stability of the preclinical episodic memory deficit in Alzheimer's disease. Brain 124, 96–102. 10.1093/brain/124.1.96 11133790 [OpenAIRE] [PubMed] [DOI]

Bennett D. A.De Jager P. L.Leurgans S. E.Schneider J. A. (2009). Neuropathologic intermed iate phenotypes enhance association to Alzheimer susceptibility alleles. Neurology 72, 1495–1503. 10.1212/WNL.0b013e3181a2e87d 19398704 [OpenAIRE] [PubMed] [DOI]

Berbee J. F.Vanmierlo T.Abildayeva K.Blokland A.Jansen P. J.Lutjohann D.. (2011). Apolipoprotein CI knock-out mice display impaired memory functions. J. Alzheimers. Dis. 23, 737–747. 10.3233/JAD-2010-100576 21157034 [OpenAIRE] [PubMed] [DOI]

Burgess J. D.Pedraza O.Graff-Radford N. R.Hirpa M.Zou F. G.Miles R.. (2011). Association of common KIBRA variants with episodic memory and AD risk. Neurobiol. Aging 32, 557.e1–557.e9. 10.1016/j.neurobiolaging.2010.11.004 21185624 [OpenAIRE] [PubMed] [DOI]

Caberlotto L.Lauria M.Nguyen T. P.Scotti M. (2013). The central role of AMP-Kinase and energy homeostasis impairment in Alzheimer's disease: a multifactor network analysis. PLoS ONE 8:e78919. 10.1371/journal.pone.0078919 24265728 [OpenAIRE] [PubMed] [DOI]

Egan M. F.Kojima M.Callicott J. H.Goldberg T. E.Kolachana B. S.Bertolino A.. (2003). The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell 112, 257–269. 10.1016/S0092-8674(03)00035-7 12553913 [OpenAIRE] [PubMed] [DOI]

Ertekin-Taner N. (2010). Genetics of Alzheimer disease in the pre- and post-GWAS era. Alzheimers Res. Ther. 2, 3. 10.1186/alzrt26 20236449 [OpenAIRE] [PubMed] [DOI]

Franceschini A.Szklarczyk D.Frankild S.Kuhn M.Simonovic M.Roth A.. (2013). STRING v9.1: protein-protein interaction networks, with increased coverage and integration. Nucleic Acids Res. 41, D808–D815. 10.1093/nar/gks1094 23203871 [OpenAIRE] [PubMed] [DOI]

Furney S. J.Simmons A.Breen G.Pedroso I.Lunnon K.Proitsi P.. (2011). Genome-wide ass ociation with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease. Mol. Psychiatry 16, 1130–1138. 10.1038/mp.2010.123 21116278 [OpenAIRE] [PubMed] [DOI]

Gatz M.Reynolds C. A.Fratiglioni L.Johansson B.Mortimer J. A.Berg S.. (2006). Role of genes and environments for explaining Alzheimer disease. Arch. Gen. Psychiatry 63, 168–174. 10.1001/archpsyc.63.2.168 16461860 [OpenAIRE] [PubMed] [DOI]

Ghani M.Pinto D.Lee J. H.Grinberg Y.Sato C.Moreno D.. (2012). Genome-wide survey of large rare copy number variants in Alzheimer's disease among caribbean hispanics. G3 2, 71–78. 10.1534/g3.111.000869 22384383 [OpenAIRE] [PubMed] [DOI]

Glahn D. C.Almasy L.Blangero J.Burk G. M.Estrada J.Peralta J. M.. (2007). Adjudicating neurocognitive endophenotypes for schizophrenia. Am. J. Med. Genet. B Neuropsychiatr. Genet. 144B, 242–249. 10.1002/ajmg.b.30446 17034022 [OpenAIRE] [PubMed] [DOI]

Gottesman I. I Gould T. D. (2003). The endophenotype concept in psychiatry: etymology and strategic intentions. Am. J. Psychiatry 160, 636–645. 10.1176/appi.ajp.160.4.636 12668349 [OpenAIRE] [PubMed] [DOI]

Harold D.Abraham R.Hollingworth P.Sims R.Gerrish A.Hamshere M. L.. (2009). Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease. Nat. Genet. 41, 1088–1093. 10.1038/ng.440 19734902 [OpenAIRE] [PubMed] [DOI]

Herold C.Steffens M.Brockschmidt F. F.Baur M. P.Becker T. (2009). INTERSNP: genome-wide interaction analysis guided by a priori information. Bioinformatics 25, 3275–3281. 10.1093/bioinformatics/btp596 19837719 [OpenAIRE] [PubMed] [DOI]

48 references, page 1 of 4
Abstract
As the most common type of dementia, Alzheimer’s disease (AD) is a neurodegenerative disorder initially manifested by impaired memory performances. While the diagnosis information indicates a dichotomous status of a patient, memory scores have the potential to capture the continuous nature of the disease progression and may provide more insights into the underlying mechanism. In this work, we performed a targeted genetic study of memory scores on an AD cohort to identify the associations between a set of genes highly expressed in the hippocampal region and seven cognitive scores related to episodic memory. Both main effects and interaction effects of the targete...
Subjects
free text keywords: Genetics, genetic associate study, correlated phenotypes, hippocampus, episodic memory, Alzheimer's disease, Original Research, Alzheimer’s disease, QH426-470, Cognition, Genetic marker, Dementia, medicine.disease, medicine, Impaired memory, Biology, Bioinformatics, Disease, Apolipoprotein E
Funded by
NIH| Bioinformatics Strategies for Multidimensional Brain Imaging Genetics
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5R01LM011360-03
  • Funding stream: NATIONAL LIBRARY OF MEDICINE
,
NSF| III: Small: Collaborative Research: A Large-Scale Data Mining Framework for Genome-Wide Mapping of Multi-Modal Phenotypic Biomarkers and Outcome Prediction
Project
  • Funder: National Science Foundation (NSF)
  • Project Code: 1117335
  • Funding stream: Directorate for Computer & Information Science & Engineering | Division of Information and Intelligent Systems
,
NIH| Alzheimers Disease Neuroimaging Initiative
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 1U01AG024904-01
  • Funding stream: NATIONAL INSTITUTE ON AGING
,
NIH| Bioinformatics Strategies for Genome-Wide Association Studies
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5R01LM010098-08
  • Funding stream: NATIONAL LIBRARY OF MEDICINE
,
NIH| Amyloid Imaging, VMCI, and Analysis for ADNI
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 1RC2AG036535-01
  • Funding stream: NATIONAL INSTITUTE ON AGING
48 references, page 1 of 4

Backman L.Small B. J.Fratiglioni L. (2001). Stability of the preclinical episodic memory deficit in Alzheimer's disease. Brain 124, 96–102. 10.1093/brain/124.1.96 11133790 [OpenAIRE] [PubMed] [DOI]

Bennett D. A.De Jager P. L.Leurgans S. E.Schneider J. A. (2009). Neuropathologic intermed iate phenotypes enhance association to Alzheimer susceptibility alleles. Neurology 72, 1495–1503. 10.1212/WNL.0b013e3181a2e87d 19398704 [OpenAIRE] [PubMed] [DOI]

Berbee J. F.Vanmierlo T.Abildayeva K.Blokland A.Jansen P. J.Lutjohann D.. (2011). Apolipoprotein CI knock-out mice display impaired memory functions. J. Alzheimers. Dis. 23, 737–747. 10.3233/JAD-2010-100576 21157034 [OpenAIRE] [PubMed] [DOI]

Burgess J. D.Pedraza O.Graff-Radford N. R.Hirpa M.Zou F. G.Miles R.. (2011). Association of common KIBRA variants with episodic memory and AD risk. Neurobiol. Aging 32, 557.e1–557.e9. 10.1016/j.neurobiolaging.2010.11.004 21185624 [OpenAIRE] [PubMed] [DOI]

Caberlotto L.Lauria M.Nguyen T. P.Scotti M. (2013). The central role of AMP-Kinase and energy homeostasis impairment in Alzheimer's disease: a multifactor network analysis. PLoS ONE 8:e78919. 10.1371/journal.pone.0078919 24265728 [OpenAIRE] [PubMed] [DOI]

Egan M. F.Kojima M.Callicott J. H.Goldberg T. E.Kolachana B. S.Bertolino A.. (2003). The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell 112, 257–269. 10.1016/S0092-8674(03)00035-7 12553913 [OpenAIRE] [PubMed] [DOI]

Ertekin-Taner N. (2010). Genetics of Alzheimer disease in the pre- and post-GWAS era. Alzheimers Res. Ther. 2, 3. 10.1186/alzrt26 20236449 [OpenAIRE] [PubMed] [DOI]

Franceschini A.Szklarczyk D.Frankild S.Kuhn M.Simonovic M.Roth A.. (2013). STRING v9.1: protein-protein interaction networks, with increased coverage and integration. Nucleic Acids Res. 41, D808–D815. 10.1093/nar/gks1094 23203871 [OpenAIRE] [PubMed] [DOI]

Furney S. J.Simmons A.Breen G.Pedroso I.Lunnon K.Proitsi P.. (2011). Genome-wide ass ociation with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease. Mol. Psychiatry 16, 1130–1138. 10.1038/mp.2010.123 21116278 [OpenAIRE] [PubMed] [DOI]

Gatz M.Reynolds C. A.Fratiglioni L.Johansson B.Mortimer J. A.Berg S.. (2006). Role of genes and environments for explaining Alzheimer disease. Arch. Gen. Psychiatry 63, 168–174. 10.1001/archpsyc.63.2.168 16461860 [OpenAIRE] [PubMed] [DOI]

Ghani M.Pinto D.Lee J. H.Grinberg Y.Sato C.Moreno D.. (2012). Genome-wide survey of large rare copy number variants in Alzheimer's disease among caribbean hispanics. G3 2, 71–78. 10.1534/g3.111.000869 22384383 [OpenAIRE] [PubMed] [DOI]

Glahn D. C.Almasy L.Blangero J.Burk G. M.Estrada J.Peralta J. M.. (2007). Adjudicating neurocognitive endophenotypes for schizophrenia. Am. J. Med. Genet. B Neuropsychiatr. Genet. 144B, 242–249. 10.1002/ajmg.b.30446 17034022 [OpenAIRE] [PubMed] [DOI]

Gottesman I. I Gould T. D. (2003). The endophenotype concept in psychiatry: etymology and strategic intentions. Am. J. Psychiatry 160, 636–645. 10.1176/appi.ajp.160.4.636 12668349 [OpenAIRE] [PubMed] [DOI]

Harold D.Abraham R.Hollingworth P.Sims R.Gerrish A.Hamshere M. L.. (2009). Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease. Nat. Genet. 41, 1088–1093. 10.1038/ng.440 19734902 [OpenAIRE] [PubMed] [DOI]

Herold C.Steffens M.Brockschmidt F. F.Baur M. P.Becker T. (2009). INTERSNP: genome-wide interaction analysis guided by a priori information. Bioinformatics 25, 3275–3281. 10.1093/bioinformatics/btp596 19837719 [OpenAIRE] [PubMed] [DOI]

48 references, page 1 of 4
Powered by OpenAIRE Research Graph
Any information missing or wrong?Report an Issue