Effects of S-Propargyl-Cysteine (SPRC) in Caerulein-Induced Acute Pancreatitis in Mice

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Jenab N Sidhapuriwala; Akhil Hegde; Abel D Ang; Yi Zhun Zhu; Madhav Bhatia;
  • Publisher: Public Library of Science
  • Journal: PLoS ONE,volume 7,issue 3 (issn: 1932-6203, eissn: 1932-6203)
  • Publisher copyright policies & self-archiving
  • Related identifiers: doi: 10.1371/journal.pone.0032574, pmc: PMC3291555
  • Subject: Animal Models | Research Article | Biology | Immune Physiology | Gastroenterology and Hepatology | Medicine | Immunity | Drug Research and Development | Anatomy and Physiology | Q | R | Model Organisms | Drugs and Devices | Clinical Immunology | Pancreas | Science | Immunology

Hydrogen sulfide (H(2)S), a novel gaseous messenger, is synthesized endogenously from L-cysteine by two pyridoxal-5'-phosphate-dependent enzymes, cystathionine β-synthase (CBS) and cystathionine γ-lyase (CSE). S-propargyl-cysteine (SPRC) is a slow H(2)S releasing drug t... View more
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