A critical examination of the recently reported crystal structures of the human SMN protein

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Weiss, Manfred S.; Diederichs, Kay; Read, Randy J.; Panjikar, Santosh; Van Duyne, Gregory D.; Matera, A. Gregory; Fischer, Utz; Grimm, Clemens;

A recent publication by Seng et al. in this journal reports the crystallographic structure of refolded, full-length SMN protein and two disease-relevant derivatives thereof. Here, we would like to suggest that at least two of the structures reported in that study are in... View more
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