publication . Article . 2006

Overexpression of a Drosophila homolog of apolipoprotein D leads to increased stress resistance and extended lifespan.

Julien Muffat; Julien Muffat; Seymour Benzer; David W. Walker; Colin Rundel;
Open Access English
  • Published: 04 Apr 2006 Journal: Current Biology, issue 7, pages 674-679 (issn: 09609822, Copyright policy)
  • Publisher: Elsevier Ltd.
  • Country: United States
Summary Increased Apolipoprotein D (ApoD) expression has been reported in various neurological disorders, including Alzheimer's disease, schizophrenia, and stroke, and in the aging brain [1]. However, whether ApoD is toxic or a defense is unknown. In a screen to identify genes that protect Drosophila against acute oxidative stress, we isolated a fly homolog of ApoD, Glial Lazarillo ( GLaz ). In independent transgenic lines, overexpression of GLaz resulted in increased resistance to hyperoxia (100% O 2 ) as well as a 29% extension of lifespan under normoxia. These flies also displayed marked improvements in climbing and walking ability after sublethal exposure to...
free text keywords: MOLNEURO, HUMDISEASE, Biochemistry, Genetics and Molecular Biology(all), Agricultural and Biological Sciences(all), General Biochemistry, Genetics and Molecular Biology, General Agricultural and Biological Sciences, Hyperoxia, medicine.symptom, medicine, Apolipoprotein D, Ischemia, medicine.disease, Reperfusion injury, Oxidative stress, medicine.disease_cause, Aging brain, Genetics, Hypoxia (medical), Cell biology, Model organism, ved/biology.organism_classification_rank.species, ved/biology, Biology
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