Co-expression Network Approach Reveals Functional Similarities among Diseases Affecting Human Skeletal Muscle

Article English OPEN
Mukund, Kavitha ; Subramaniam, Shankar (2017)
  • Publisher: Frontiers Media S.A.
  • Journal: Frontiers in Physiology, volume 8 (issn: 1664-042X, eissn: 1664-042X)
  • Related identifiers: doi: 10.3389/fphys.2017.00980, doi: 10.3389/fphys.2017.00980/full, pmc: PMC5717538
  • Subject: QP1-981 | drug repurposing | bioenergetics | calcium signaling | Physiology | human protein interaction network | neuromuscular disease | Original Research | co-expression networks | functional module framework | skeletal muscle physiology

Diseases affecting skeletal muscle exhibit considerable heterogeneity in intensity, etiology, phenotypic manifestation and gene expression. Systems biology approaches using network theory, allows for a holistic understanding of functional similarities amongst diseases. ... View more