Polaprezinc reduces paclitaxel-induced peripheral neuropathy in rats without affecting anti-tumor activity

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Kuniaki Tsutsumi; Takanori Kaname; Haruka Shiraishi; Takehiro Kawashiri; Nobuaki Egashira;
  • Publisher: Elsevier
  • Journal: Journal of Pharmacological Sciences,volume 131,issue 2,pages146-149 (issn: 1347-8613)
  • Related identifiers: doi: 10.1016/j.jphs.2016.04.019
  • Subject: Paclitaxel | Polaprezinc | RM1-950 | Therapeutics. Pharmacology | Peripheral neuropathy

Paclitaxel, an anticancer drug, frequently causes painful peripheral neuropathy. In this study, we investigated the preventive effect of polaprezinc on paclitaxel-induced peripheral neuropathy in rats. Polaprezinc (3 mg/kg, p.o., once daily) inhibited the development of... View more
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