Ouabain exacerbates activation-induced cell death in human peripheral blood lymphocytes

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Esteves, Mabel B.; Marques-Santos, Luis F.; Affonso-Mitidieri, Ottília R.; Rumjanek, Vivian M.;
  • Publisher: Academia Brasileira de Ciências
  • Journal: issn: 0001-3765, eissn: 1678-2690
  • Related identifiers: doi: 10.1590/S0001-37652005000200008
  • Subject: ouabaína | ouabain | Q | lymphocytes | membrane depolarization | Science | PHA | despolarização de membrana | apoptosis | apoptose | linfócitos

Lymphocytes activated by mitogenic lectins display changes in transmembrane potential, an elevation in the cytoplasmic Ca2+ concentrations, proliferation and/or activation induced cell death. Low concentrations of ouabain (an inhibitor of Na+,K+-ATPase) suppress mitogen... View more
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