publication . Conference object . Article . Other literature type . 2017

Bacterial protease uses distinct thermodynamic signatures for substrate recognition

Adam Round; Guillaume Hoffmann; Takayuki K. Nemoto; Sofiya Fedosyuk; Irina Cornaciu; Kristina Djinović-Carugo; Kristina Djinović-Carugo; Gustavo Arruda Bezerra; Gustavo Arruda Bezerra; Yuko Ohara-Nemoto; ...
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Open Access
  • Published: 01 Jun 2017 Journal: Scientific Reports (issn: 2045-2322, Copyright policy)
Abstract
Abstract Porphyromonas gingivalis and Porphyromonas endodontalis are important bacteria related to periodontitis, the most common chronic inflammatory disease in humans worldwide. Its comorbidity with systemic diseases, such as type 2 diabetes, oral cancers and cardiovascular diseases, continues to generate considerable interest. Surprisingly, these two microorganisms do not ferment carbohydrates; rather they use proteinaceous substrates as carbon and energy sources. However, the underlying biochemical mechanisms of their energy metabolism remain unknown. Here, we show that dipeptidyl peptidase 11 (DPP11), a central metabolic enzyme in these bacteria, undergoes ...
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doi: 10.1038/s41598-017-03220-y
pmid: 28588213
pmc: PMC5460201
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Subjects
free text keywords: Medicine, R, Science, Q, Article, Bacteria, Enzyme mechanisms, Thermodynamics, X-ray crystallography, Biochemistry, Biology, Enzyme, chemistry.chemical_classification, chemistry, Porphyromonas gingivalis, biology.organism_classification, Protease, medicine.medical_treatment, Peptide binding, Dipeptidyl peptidase, Conformational change, Conformational entropy, Energy source
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Funded by
FWF| The large phosphoprotein of human cytomegalovirus
Project
The large phosphoprotein of human cytomegalovirus
  • Funder: Austrian Science Fund (FWF) (FWF)
  • Project Code: P 25353
  • Funding stream: Einzelprojekte
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67 references, page 1 of 5

1. Eke, P. I. et al. Update on Prevalence of Periodontitis in Adults in the United States: NHANES 2009 to 2012. J. Periodontol. 86, 611-622 (2015).

2. Batchelor, P. Is periodontal disease a public health problem? Br. Dent. J. 217, 405-409 (2014).

3. Chee, B., Park, B. & Bartold, P. M. Periodontitis and type II diabetes: a two-way relationship. Int. J. Evid. Based Healthc. 11, 317-329 (2013).

4. Hajishengallis, G., Darveau, R. P. & Curtis, M. A. eTh keystone-pathogen hypothesis. Nat. Rev. Microbiol. 10, 717-725 (2012). [OpenAIRE]

5. Lombardo Bedran, T. B. et al. Porphyromonas endodontalis in chronic periodontitis: a clinical and microbiological cross-sectional study. J. Oral Microbiol. 4, 10123 (2012).

6. Wang, J. & Jia, H. Metagenome-wide association studies: fine-mining the microbiome. Nat. Rev. Microbiol. 14, 508-522 (2016).

7. Lalla, E. & Papapanou, P. N. Diabetes mellitus and periodontitis: a tale of two common interrelated diseases. Nat. Rev. Endocrinol. 7, 738-748 (2011). [OpenAIRE]

8. Lundberg, K., Wegner, N., Yucel-Lindberg, T. & Venables, P. J. Periodontitis in RA-the citrullinated enolase connection. Nat. Rev. Rheumatol. 6, 727-730 (2010).

9. Javed, F. & Warnakulasuriya, S. Is there a relationship between periodontal disease and oral cancer? A systematic review of currently available evidence. Crit. Rev. Oncol. Hematol. 97, 197-205 (2015). [OpenAIRE]

10. Ha, N. H. et al. Prolonged and repetitive exposure to Porphyromonas gingivalis increases aggressiveness of oral cancer cells by promoting acquisition of cancer stem cell properties. Tumour Biol. 36, 9947-9960 (2015).

11. Ruiz, I. F. Risk factors: Periodontitis increases risk of a first MI. Nat. Rev. Cardiol. 13, 124 (2016).

12. Farhad, S. Z. et al. eTh eefct of chronic periodontitis on serum levels of tumor necrosis factor-alpha in Alzheimer disease. Dent. Res. J. (Isfahan) 11, 549-552 (2014). [OpenAIRE]

13. Paju, S. & Scannapieco, F. A. Oral biofilms, periodontitis, and pulmonary infections. Oral Dis. 13, 508-512 (2007). [OpenAIRE]

14. Hajishengallis, G. Periodontitis: from microbial immune subversion to systemic inaflmmation. Nat. Rev. Immunol. 15, 30-44 (2015).

15. Rouf, S. M. et al. Phenylalanine 664 of dipeptidyl peptidase (DPP) 7 and Phenylalanine 671 of DPP11 mediate preference for P2- position hydrophobic residues of a substrate. FEBS Open Bio 3, 177-183 (2013). [OpenAIRE]

67 references, page 1 of 5
Abstract
Abstract Porphyromonas gingivalis and Porphyromonas endodontalis are important bacteria related to periodontitis, the most common chronic inflammatory disease in humans worldwide. Its comorbidity with systemic diseases, such as type 2 diabetes, oral cancers and cardiovascular diseases, continues to generate considerable interest. Surprisingly, these two microorganisms do not ferment carbohydrates; rather they use proteinaceous substrates as carbon and energy sources. However, the underlying biochemical mechanisms of their energy metabolism remain unknown. Here, we show that dipeptidyl peptidase 11 (DPP11), a central metabolic enzyme in these bacteria, undergoes ...
Read more
doi: 10.1038/s41598-017-03220-y
pmid: 28588213
pmc: PMC5460201
View all 4 identifiers
Subjects
free text keywords: Medicine, R, Science, Q, Article, Bacteria, Enzyme mechanisms, Thermodynamics, X-ray crystallography, Biochemistry, Biology, Enzyme, chemistry.chemical_classification, chemistry, Porphyromonas gingivalis, biology.organism_classification, Protease, medicine.medical_treatment, Peptide binding, Dipeptidyl peptidase, Conformational change, Conformational entropy, Energy source
Related Organizations
View more
Funded by
FWF| The large phosphoprotein of human cytomegalovirus
Project
The large phosphoprotein of human cytomegalovirus
  • Funder: Austrian Science Fund (FWF) (FWF)
  • Project Code: P 25353
  • Funding stream: Einzelprojekte
Download fromView all 7 versions
Scientific Reports
Article . 2017
Provider: DOAJ-Articles
Scientific Reports
Article . 2017
Provider: Crossref
Scientific Reports
Article
Provider: UnpayWall
Scientific Reports
Article
Provider: Microsoft Academic Graph
View more
67 references, page 1 of 5

1. Eke, P. I. et al. Update on Prevalence of Periodontitis in Adults in the United States: NHANES 2009 to 2012. J. Periodontol. 86, 611-622 (2015).

2. Batchelor, P. Is periodontal disease a public health problem? Br. Dent. J. 217, 405-409 (2014).

3. Chee, B., Park, B. & Bartold, P. M. Periodontitis and type II diabetes: a two-way relationship. Int. J. Evid. Based Healthc. 11, 317-329 (2013).

4. Hajishengallis, G., Darveau, R. P. & Curtis, M. A. eTh keystone-pathogen hypothesis. Nat. Rev. Microbiol. 10, 717-725 (2012). [OpenAIRE]

5. Lombardo Bedran, T. B. et al. Porphyromonas endodontalis in chronic periodontitis: a clinical and microbiological cross-sectional study. J. Oral Microbiol. 4, 10123 (2012).

6. Wang, J. & Jia, H. Metagenome-wide association studies: fine-mining the microbiome. Nat. Rev. Microbiol. 14, 508-522 (2016).

7. Lalla, E. & Papapanou, P. N. Diabetes mellitus and periodontitis: a tale of two common interrelated diseases. Nat. Rev. Endocrinol. 7, 738-748 (2011). [OpenAIRE]

8. Lundberg, K., Wegner, N., Yucel-Lindberg, T. & Venables, P. J. Periodontitis in RA-the citrullinated enolase connection. Nat. Rev. Rheumatol. 6, 727-730 (2010).

9. Javed, F. & Warnakulasuriya, S. Is there a relationship between periodontal disease and oral cancer? A systematic review of currently available evidence. Crit. Rev. Oncol. Hematol. 97, 197-205 (2015). [OpenAIRE]

10. Ha, N. H. et al. Prolonged and repetitive exposure to Porphyromonas gingivalis increases aggressiveness of oral cancer cells by promoting acquisition of cancer stem cell properties. Tumour Biol. 36, 9947-9960 (2015).

11. Ruiz, I. F. Risk factors: Periodontitis increases risk of a first MI. Nat. Rev. Cardiol. 13, 124 (2016).

12. Farhad, S. Z. et al. eTh eefct of chronic periodontitis on serum levels of tumor necrosis factor-alpha in Alzheimer disease. Dent. Res. J. (Isfahan) 11, 549-552 (2014). [OpenAIRE]

13. Paju, S. & Scannapieco, F. A. Oral biofilms, periodontitis, and pulmonary infections. Oral Dis. 13, 508-512 (2007). [OpenAIRE]

14. Hajishengallis, G. Periodontitis: from microbial immune subversion to systemic inaflmmation. Nat. Rev. Immunol. 15, 30-44 (2015).

15. Rouf, S. M. et al. Phenylalanine 664 of dipeptidyl peptidase (DPP) 7 and Phenylalanine 671 of DPP11 mediate preference for P2- position hydrophobic residues of a substrate. FEBS Open Bio 3, 177-183 (2013). [OpenAIRE]

67 references, page 1 of 5
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