publication . Article . Other literature type . Conference object . 2018

Matched Short-Term Depression and Recovery Encodes Interspike Interval at a Central Synapse.

Jeremy E. Niven; Sergio Rossoni; Sergio Rossoni; Armando E. Castillo;
Open Access English
  • Published: 11 Sep 2018 Journal: Scientific Reports (issn: 2045-2322, Copyright policy)
  • Publisher: Nature Publishing Group
  • Country: United Kingdom
Abstract Reversible decreases in synaptic strength, known as short-term depression (STD), are widespread in neural circuits. Various computational roles have been attributed to STD but these tend to focus upon the initial depression rather than the subsequent recovery. We studied the role of STD and recovery at an excitatory synapse between the fast extensor tibiae (FETi) and flexor tibiae (flexor) motor neurons in the desert locust (Schistocerca gregaria) by making paired intracellular recordings in vivo. Over behaviorally relevant pre-synaptic spike frequencies, we found that this synapse undergoes matched frequency-dependent STD and recovery; higher frequency...
free text keywords: Medicine, R, Science, Q, Multidisciplinary, Article, Epsp amplitude, FETI, Schistocerca, biology.organism_classification, biology, Neuroscience, Excitatory postsynaptic potential, Chemistry, Biological neural network, Excitatory synapse, Synapse, Time constant
49 references, page 1 of 4

Abbott, LF, Varela, JA, Sen, K, Nelson, SB. Synaptic depression and cortical gain control. Science.. 1997; 275: 221-224 [OpenAIRE] [DOI]

O’Donovan, MJ, Rinzel, J. Synaptic depression: A dynamic regulator of synaptic communication with varied functional roles. Trends in Neurosciences. 1997; 20: 431-433 [OpenAIRE] [PubMed] [DOI]

Abbott, LF, Regehr, WG. Synaptic computation. Nature. 2004; 431: 796-803 [OpenAIRE] [PubMed] [DOI]

Pfister, J, Dayan, P, Lengyel, M. Synapses with short-term plasticity are optimal estimators of presynaptic membrane potentials. Nature. 2010; 13: 1271-1275

Wang, LY, Kaczmarek, LK. High-frequency firing helps replenish the readily releasable pool of synaptic vesicles. Nature. 1998; 394: 384-388 [OpenAIRE] [PubMed] [DOI]

Parker, D. Depression of synaptic connections between identified motor neurons in the locust. J. Neurophysiol.. 1995; 74: 529-538 [OpenAIRE] [PubMed] [DOI]

Wang, Y, Manis, PB. Short-term synaptic depression and recovery at the mature mammalian endbulb of Held synapse in mice. J. Neurophysiol.. 2008; 100: 1255-1264 [OpenAIRE] [PubMed] [DOI]

Cho, S, Li, G, von Gersdorff, H. Recovery from short-term depression and facilitation is ultrafast and Ca2+ dependent at auditory hair cell synapses. J. Neurosci.. 2011; 31: 5682-92 [OpenAIRE] [PubMed] [DOI]

Dittman, JS, Regehr, WG. Calcium dependence and recovery kinetics of presynaptic depression at the climbing fiber to Purkinje cell synapse. J. Neurosci.. 1998; 18: 6147-62 [OpenAIRE] [PubMed] [DOI]

Burrows, M, Watson, AHD, Brunn, DE. Physiological and ultrastructural characterization of a central synaptic connection between identified motor neurons in the locust. Eur. J. Neurosci.. 1989; 1: 111-126 [OpenAIRE] [PubMed] [DOI]

Niven, JE, Burrows, M. Spike width reduction modifies the dynamics of short-term depression at a central synapse in the locust. J. Neurosci.. 2003; 23: 7461-9 [OpenAIRE] [PubMed] [DOI]

Sasaki, K, Burrows, M. Innervation pattern of a pool of nine excitatory motor neurons in the flexor tibiae muscle of a locust hind leg. J. Exp. Biol.. 1998; 201 (Pt 12): 1885-93 [PubMed]

Hoyle, G, Burrows, M. Neural mechanisms underlying behavior in the locust Schistocerca gregaria. II. Integrative activity in metathoracic neurons. J. Neurobiol.. 1973; 4: 43-67 [OpenAIRE] [PubMed] [DOI]

Gwilliam, BYGF, Burrows, M. Electrical characteristics of the membrane of an identified insect motor neurone. J. Exp. Biol.. 1980; 86: 49-61

Markram, H, Tsodyks, M. The neural code between neocortical pyramidal neurons depends. Proc. Natl. Acad. Sci. USA. 1997; 94: 719-723 [OpenAIRE] [PubMed] [DOI]

49 references, page 1 of 4
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