Inactivation of the type I interferon pathway reveals long double-stranded RNA-mediated RNA interference in mammalian cells.

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Maillard, P. V.; Van der Veen, A. G.; Deddouche-Grass, S.; Rogers, N. C.; Merits, A.; Reis E Sousa, C.;
  • Publisher: John Wiley and Sons Inc.
  • Journal: The EMBO Journal,volume 35,issue 23,pages2,505-2,518 (issn: 0261-4189, eissn: 1460-2075)
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  • Related identifiers: doi: 10.15252/embj.201695086, pmc: PMC5167344
  • Subject: viral infection | innate immunity | RNA interference, double‐stranded RNA, innate immunity, viral infection, Animals, Cells, Cultured, Gene Expression Regulation, Immunity, Innate, Interferon Type I, Mice, RNA Interference, RNA Viruses, RNA, Double-Stranded, RNA, Viral | RNA Biology | Articles | RNA interference | Immunology | Article | double‐stranded RNA
    mesheuropmc: fungi

Abstract RNA interference (RNAi) elicited by long double‐stranded (ds) or base‐paired viral RNA constitutes the major mechanism of antiviral defence in plants and invertebrates. In contrast, it is controversial whether it acts in chordates. Rather, in vertebrates, viral... View more
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