publication . Article . 2015

Population Pharmacokinetics of an Indian F(ab')2 Snake Antivenom in Patients with Russell's Viper (Daboia russelii) Bites.

Isbister, Geoffrey K.; Maduwage, Kalana; Saiao, Ana; Buckley, Nicholas A.; Jayamanne, Shaluka F.; Seyed, Shahmy; Mohamed, Fahim; Chathuranga, Umesh; Alexandre, Mendes; Abeysinghe, Chandana; ...
Open Access English
  • Published: 01 Jul 2015 Journal: PLoS Neglected Tropical Diseases, volume 9, issue 7 (issn: 1935-2727, eissn: 1935-2735, Copyright policy)
  • Publisher: Public Library of Science (PLoS)
Abstract
Background\ud \ud There is limited information on antivenom pharmacokinetics. This study aimed to investigate the pharmacokinetics of an Indian snake antivenom in humans with Russell’s viper bites.\ud \ud Methods/Principal Findings\ud \ud Patient data and serial blood samples were collected from patients with Russell’s viper (Daboia russelii) envenoming in Sri Lanka. All patients received Indian F(ab’)2 snake antivenom manufactured by VINS Bioproducts Ltd. Antivenom concentrations were measured with sandwich enzyme immunoassays. Timed antivenom concentrations were analysed using MONOLIXvs4.2. One, two and three compartment models with zero order input and first ...
Subjects
mesheuropmc: complex mixtures
free text keywords: qv_38, RC955-962, qv_601, Research Article, RA1-1270, Public aspects of medicine, wd_410, Arctic medicine. Tropical medicine
25 references, page 1 of 2

1. Kasturiratne A, Wickremasinghe AR, de Silva N, Gunawardena NK, Pathmeswaran A, Premaratna R, Savioli L, Lalloo DG, de Silva HJ. The global burden of snakebite: a literature analysis and modelling based on regional estimates of envenoming and deaths. PLoSMed 2008; 5: e218.

2. Gawarammana IB, Kularatne SAM, Dissanayake WP, et al. Parallel infusion of hydrocortisone ñ chlorpheniramine bolus injection to prevent acute adverse reactions to antivenom for snakebites. Medical Journal of Australia 2004; 180: 20-3.

3. de Silva HA, Pathmeswaran A, Ranasinha CD, Jayamanne S, Samarakoon SB, Hittharage A, Kalupahana R, Ratnatilaka GA, Uluwatthage W, Aronson JK, Armitage JM, Lalloo DG, de Silva HJ. Low-dose adrenaline, promethazine, and hydrocortisone in the prevention of acute adverse reactions to antivenom following snakebite: a randomised, double-blind, placebo-controlled trial. PLoS Med 2011; 8: e1000435.

4. Gutierrez JM, Leon G, Lomonte B. Pharmacokinetic-pharmacodynamic relationships of immunoglobulin therapy for envenomation. ClinPharmacokinet 2003; 42: 721-41.

5. Ariaratnam CA, Meyer WP, Perera G, Eddleston M, Kuleratne SA, Attapattu W, Sheriff R, Richards AM, Theakston RD, Warrell DA. A new monospecific ovine Fab fragment antivenom for treatment of envenoming by the Sri Lankan Russell's viper (Daboia Russelii Russelii): a preliminary dose-finding and pharmacokinetic study. American Journal of Tropical Medicine & Hygiene 1999; 61: 259-65.

6. Isbister GK, Shahmy S, Mohamed F, Abeysinghe C, Karunathilake H, Ariaratnam A. A randomised controlled trial of two infusion rates to decrease reactions to antivenom. PLoS One 2012; 7: e38739.

7. Fox S, Rathuwithana AC, Kasturiratne A, Lalloo DG, de Silva HJ. Underestimation of snakebite mortality by hospital statistics in the Monaragala District of Sri Lanka. Transactions of the Royal Society of Tropical Medicine and Hygiene 2006; 100: 693-5.

8. Kulawickrama S, O'Leary MA, Hodgson WC, Brown SG, Jacoby T, Davern K, Isbister GK. Development of a sensitive enzyme immunoassay for measuring taipan venom in serum. Toxicon 2010; 55: 1510-8.

9. Ho M, Silamut K, White NJ, Karbwang J, Looareesuwan S, Phillips RE, Warrell DA. Pharmacokinetics of three commercial antivenoms in patients envenomed by the Malayan pit viper, Calloselasma rhodostoma, in Thailand. American Journal of Tropical Medicine and Hygiene 1990; 42: 260-6.

10. Rojas A, Vargas M, Ramirez N, Estrada R, Segura A, Herrera M, Villalta M, Gomez A, Gutierrez JM, Leon G. Role of the animal model on the pharmacokinetics of equine-derived antivenoms. Toxicon 2013; 70: 9-14.

11. Meyer WP, Habib AG, Onayade AA, Yakubu A, Smith DC, Nasidi A, Daudu IJ, Warrell DA, Theakston RD. First clinical experiences with a new ovine Fab Echis ocellatus snake bite antivenom in Nigeria: randomized comparative trial with Institute Pasteur Serum (Ipser) Africa antivenom. American Journal of Tropical Medicine & Hygiene 1997; 56: 291-300.

12. Thein T, Kyi T, Mg Mg T. Plasma clearance time of Russell's viper (Vipera russelli) antivenom in human snake bite victims. Trans R Soc Trop Med Hyg 1985; 79: 262-3.

13. Seifert SA, Boyer LV. Recurrence phenomena after immunoglobulin therapy for snake envenomations: Part 1. Pharmacokinetics and pharmacodynamics of immunoglobulin antivenoms and related antibodies. [Review] [49 refs]. Annals of Emergency Medicine 2001; 37: 189-95.

14. Vazquez H, Chavez-Haro A, Garcia-Ubbelohde W, Mancilla-Nava R, Paniagua-Solis J, Alagon A, Sevcik C. Pharmacokinetics of a F(ab')2 scorpion antivenom in healthy human volunteers. Toxicon 2005; 46: 797-805.

15. Isbister GK, Maduwage K, Shahmy S, Mohamed F, Abeysinghe C, Karunathilake H, Ariaratnam CA, Buckley NA. Diagnostic 20-min whole blood clotting test in Russell's viper envenoming delays antivenom administration. QJM 2013; 106: 925-32.

25 references, page 1 of 2
Abstract
Background\ud \ud There is limited information on antivenom pharmacokinetics. This study aimed to investigate the pharmacokinetics of an Indian snake antivenom in humans with Russell’s viper bites.\ud \ud Methods/Principal Findings\ud \ud Patient data and serial blood samples were collected from patients with Russell’s viper (Daboia russelii) envenoming in Sri Lanka. All patients received Indian F(ab’)2 snake antivenom manufactured by VINS Bioproducts Ltd. Antivenom concentrations were measured with sandwich enzyme immunoassays. Timed antivenom concentrations were analysed using MONOLIXvs4.2. One, two and three compartment models with zero order input and first ...
Subjects
mesheuropmc: complex mixtures
free text keywords: qv_38, RC955-962, qv_601, Research Article, RA1-1270, Public aspects of medicine, wd_410, Arctic medicine. Tropical medicine
25 references, page 1 of 2

1. Kasturiratne A, Wickremasinghe AR, de Silva N, Gunawardena NK, Pathmeswaran A, Premaratna R, Savioli L, Lalloo DG, de Silva HJ. The global burden of snakebite: a literature analysis and modelling based on regional estimates of envenoming and deaths. PLoSMed 2008; 5: e218.

2. Gawarammana IB, Kularatne SAM, Dissanayake WP, et al. Parallel infusion of hydrocortisone ñ chlorpheniramine bolus injection to prevent acute adverse reactions to antivenom for snakebites. Medical Journal of Australia 2004; 180: 20-3.

3. de Silva HA, Pathmeswaran A, Ranasinha CD, Jayamanne S, Samarakoon SB, Hittharage A, Kalupahana R, Ratnatilaka GA, Uluwatthage W, Aronson JK, Armitage JM, Lalloo DG, de Silva HJ. Low-dose adrenaline, promethazine, and hydrocortisone in the prevention of acute adverse reactions to antivenom following snakebite: a randomised, double-blind, placebo-controlled trial. PLoS Med 2011; 8: e1000435.

4. Gutierrez JM, Leon G, Lomonte B. Pharmacokinetic-pharmacodynamic relationships of immunoglobulin therapy for envenomation. ClinPharmacokinet 2003; 42: 721-41.

5. Ariaratnam CA, Meyer WP, Perera G, Eddleston M, Kuleratne SA, Attapattu W, Sheriff R, Richards AM, Theakston RD, Warrell DA. A new monospecific ovine Fab fragment antivenom for treatment of envenoming by the Sri Lankan Russell's viper (Daboia Russelii Russelii): a preliminary dose-finding and pharmacokinetic study. American Journal of Tropical Medicine & Hygiene 1999; 61: 259-65.

6. Isbister GK, Shahmy S, Mohamed F, Abeysinghe C, Karunathilake H, Ariaratnam A. A randomised controlled trial of two infusion rates to decrease reactions to antivenom. PLoS One 2012; 7: e38739.

7. Fox S, Rathuwithana AC, Kasturiratne A, Lalloo DG, de Silva HJ. Underestimation of snakebite mortality by hospital statistics in the Monaragala District of Sri Lanka. Transactions of the Royal Society of Tropical Medicine and Hygiene 2006; 100: 693-5.

8. Kulawickrama S, O'Leary MA, Hodgson WC, Brown SG, Jacoby T, Davern K, Isbister GK. Development of a sensitive enzyme immunoassay for measuring taipan venom in serum. Toxicon 2010; 55: 1510-8.

9. Ho M, Silamut K, White NJ, Karbwang J, Looareesuwan S, Phillips RE, Warrell DA. Pharmacokinetics of three commercial antivenoms in patients envenomed by the Malayan pit viper, Calloselasma rhodostoma, in Thailand. American Journal of Tropical Medicine and Hygiene 1990; 42: 260-6.

10. Rojas A, Vargas M, Ramirez N, Estrada R, Segura A, Herrera M, Villalta M, Gomez A, Gutierrez JM, Leon G. Role of the animal model on the pharmacokinetics of equine-derived antivenoms. Toxicon 2013; 70: 9-14.

11. Meyer WP, Habib AG, Onayade AA, Yakubu A, Smith DC, Nasidi A, Daudu IJ, Warrell DA, Theakston RD. First clinical experiences with a new ovine Fab Echis ocellatus snake bite antivenom in Nigeria: randomized comparative trial with Institute Pasteur Serum (Ipser) Africa antivenom. American Journal of Tropical Medicine & Hygiene 1997; 56: 291-300.

12. Thein T, Kyi T, Mg Mg T. Plasma clearance time of Russell's viper (Vipera russelli) antivenom in human snake bite victims. Trans R Soc Trop Med Hyg 1985; 79: 262-3.

13. Seifert SA, Boyer LV. Recurrence phenomena after immunoglobulin therapy for snake envenomations: Part 1. Pharmacokinetics and pharmacodynamics of immunoglobulin antivenoms and related antibodies. [Review] [49 refs]. Annals of Emergency Medicine 2001; 37: 189-95.

14. Vazquez H, Chavez-Haro A, Garcia-Ubbelohde W, Mancilla-Nava R, Paniagua-Solis J, Alagon A, Sevcik C. Pharmacokinetics of a F(ab')2 scorpion antivenom in healthy human volunteers. Toxicon 2005; 46: 797-805.

15. Isbister GK, Maduwage K, Shahmy S, Mohamed F, Abeysinghe C, Karunathilake H, Ariaratnam CA, Buckley NA. Diagnostic 20-min whole blood clotting test in Russell's viper envenoming delays antivenom administration. QJM 2013; 106: 925-32.

25 references, page 1 of 2
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publication . Article . 2015

Population Pharmacokinetics of an Indian F(ab')2 Snake Antivenom in Patients with Russell's Viper (Daboia russelii) Bites.

Isbister, Geoffrey K.; Maduwage, Kalana; Saiao, Ana; Buckley, Nicholas A.; Jayamanne, Shaluka F.; Seyed, Shahmy; Mohamed, Fahim; Chathuranga, Umesh; Alexandre, Mendes; Abeysinghe, Chandana; ...