Upregulation of Ih expressed in IB4-negative Aδ nociceptive DRG neurons contributes to mechanical hypersensitivity associated with cervical radiculopathic pain

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Da-Lu Liu ; Na Lu ; Wen-Juan Han ; Rong-Gui Chen ; Rui Cong ; Rou-Gang Xie ; Yu-Fei Zhang ; Wei-Wei Kong ; San-Jue Hu ; Ceng Luo (2015)
  • Publisher: Nature Publishing Group
  • Journal: Scientific Reports, volume 5 (issn: 2045-2322, eissn: 2045-2322)
  • Related identifiers: doi: 10.1038/srep16713, pmc: PMC4649360
  • Subject: Article
    mesheuropmc: nervous system

Cervical radiculopathy represents aberrant mechanical hypersensitivity. Primary sensory neuron’s ability to sense mechanical force forms mechanotransduction. However, whether this property undergoes activity-dependent plastic changes and underlies mechanical hypersensit... View more
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