Biosynthesis and metabolism of steroid hormones by human adrenal carcinomas

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Brown J.W.; Fishman L.M.;
  • Publisher: Associação Brasileira de Divulgação Científica
  • Journal: Brazilian Journal of Medical and Biological Research (issn: 0100-879X, eissn: 0034-7310)
  • Publisher copyright policies & self-archiving
  • Subject: metyrapone | dibutyryl cAMP | cell culture | R5-920 | Krebs cycle intermediates | Medicine (General) | steroids | ACTH | adrenal carcinoma | Biology (General) | QH301-705.5

Over a 15-year period, our university-based laboratory obtained 125 adrenal tumors, of which 15 (12%) were adrenal cortical carcinomas. Of these, 6 (40% of the carcinomas) occurred in patients with clear clinical manifestations of steroid hormone excess. Adrenal cortica... View more
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