New Auroras on the Roles of the Chromosomal Passenger Complex in Cytokinesis: Implications for Cancer Therapies

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D’Avino, Pier Paolo; Capalbo, Luisa;
  • Publisher: Frontiers Media S.A.
  • Journal: Frontiers in Oncology,volume 5 (issn: 2234-943X, eissn: 2234-943X)
  • Related identifiers: pmc: PMC4604319, doi: 10.3389/fonc.2015.00221/full, doi: 10.3389/fonc.2015.00221
  • Subject: microtubule | Aurora B | RC254-282 | cell division | anti-cancer therapies | Perspective | abscission | anticancer therapies | Oncology | Neoplasms. Tumors. Oncology. Including cancer and carcinogens
    mesheuropmc: macromolecular substances

The Chromosomal Passenger Complex (CPC), composed of a kinase component, Aurora B, the scaffolding subunit Inner Centromeric Protein (INCENP), Borealin, and Survivin, is a key regulator of cell division. It controls multiple events, from chromosome condensation in proph... View more
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