Severe Hypoglycemia due to Isolated ACTH Deficiency in Children: A New Case Report and Review of the Literature

Article, Report English OPEN
Torchinsky, Michael Y.; Wineman, Robert; Moll, George W.;
(2011)

Isolated ACTH deficiency causes life-threatening severe hypoglycemia. A 7-year-old girl with hypoglycemia due to this rare disorder is described. Our patient had undetectable plasma ACTH repeatedly and cortisol 0 mcg/dl before and after ACTH 1-24 stimulation. There was ... View more
  • References (20)
    20 references, page 1 of 2

    Hung, W., Migeon, C. J.. Hypoglycemia in a two-year-old boy with adrenocorticotropic hormone (ACTH) deficiency (probably isolated) and adrenal medullary unresponsiveness to insulin-induced hypoglycemia. Journal of Clinical Endocrinology and Metabolism. 1968; 28 (2): 146-152

    Krude, H., Biebermann, H., Schnabel, D., Tansek, M. Z., Theunissen, P., Mullis, P. E., Grüters, A.. Obesity due to proopiomelanocortin deficiency: three new cases and treatment trials with thyroid hormone and ACTH 4-10. Journal of Clinical Endocrinology and Metabolism. 2003; 88 (10): 4633-4640

    Krude, H., Biebermann, H., Luck, W., Horn, R., Brabant, G., Grüters, A.. Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans. Nature Genetics. 1998; 19 (2): 155-157

    Vallette-Kasic, S., Brue, T., Pulichino, A. M., Gueydan, M., Barlier, A., David, M., Nicolino, M., Malpuech, G., Déchelotte, P., Deal, C., Van Vliet, G., De Vroede, M., Riepe, F. G., Partsch, C. J., Sippell, W. G., Berberoglu, M., Atasay, B., De Zegher, F., Beckers, D., Kyllo, J., Donohoue, P., Fassnacht, M., Hahner, S., Allolio, B., Noordam, C., Dunkel, L., Hero, M., Pigeon, B., Weill, J., Yigit, S., Brauner, R., Heinrich, J. J., Cummings, E., Riddell, C., Enjalbert, A., Drouin, J.. Congenital isolated adrenocorticotropin deficiency: an underestimated cause of neonatal death, explained by TPIT gene mutations. Journal of Clinical Endocrinology and Metabolism. 2005; 90 (3): 1323-1331

    Weintrob, N., Drouin, J., Vallette-Kasic, S., Taub, E., Marom, D., Lebenthal, Y., Klinger, G., Bron-Harlev, E., Shohat, M.. Low estriol levels in the maternal triple-marker screen as a predictor of isolated adrenocorticotropic hormone deficiency caused by a new mutation in the TPIT gene. Pediatrics. 2006; 117 (2): e322-e327

    Martin, M. M., Martin, A. L.. Hypoglycemia due to isolated ACTH deficiency. Southern Medical Journal. 1969; 62: 1539

    Aynsley-Green, A., Moncrieff, M. W., Ratter, S.. Isolated ACTH deficiency. Metabolic and endocrine studies in a 7-year-old boy. Archives of Disease in Childhood. 1978; 53 (6): 499-502

    Bremer, A. A., Ranadive, S., Conrad, S. C., Vallette-Kasic, S., Rosenthal, S. M.. Isolated adrenocorticotropic hormone deficiency presenting as an acute neurologic emergency in a peripubertal girl. Journal of Pediatric Endocrinology and Metabolism. 2008; 21 (8): 799-803

    De Lind Van Wijngaarden, R. F. A., Otten, B. J., Festen, D. A. M., Joosten, K. F. M., De Jong, F. H., Sweep, F. C. G. J., Hokken-Koelega, A. C. S.. High prevalence of central adrenal insufficiency in patients with Prader-Willi syndrome. Journal of Clinical Endocrinology and Metabolism. 2008; 93 (5): 1649-1654

    Murch, S. H., Carter, E. P., Tsagarakis, S., Grossman, A., Savage, M. O.. Isolated ACTH deficiency with absent response to corticotrophin-releasing factor-41. Evidence for a primary pituitary defect. Acta Paediatrica Scandinavica. 1991; 80 (2): 259-261

  • Related Organizations (2)
  • Metrics
Share - Bookmark