Integrated Human Evaluation of the Lysophosphatidic Acid Pathway as a Novel Therapeutic Target in Atherosclerosis

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Aldi, Silvia; Matic, Ljubica Perisic; Hamm, Gregory; van Keulen, Daniëlle; Tempel, Dennie; Holmstrøm, Kim; Szwajda, Agnieszka; Nielsen, Boye Schnack; Emilsson, Valur; Ait-Belkacem, Rima; Lengquist, Mariette; Paulsson-Berne, Gabrielle; Eriksson, Per; Lindeman, Jan H.N.; Gool, Alain J.; Stauber, Jonathan; Hedin, Ulf; Hurt-Camejo, Eva;

Variants in the PLPP3 gene encoding for lipid phosphate phosphohydrolase 3 have been associated with susceptibility to atherosclerosis independently of classical risk factors. PLPP3 inactivates lysophosphatidic acid (LPA), a pro-inflammatory, pro-thrombotic product of p... View more
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