3-D Imaging Reveals Participation of Donor Islet Schwann Cells and Pericytes in Islet Transplantation and Graft Neurovascular Regeneration

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Juang, Jyuhn-Huarng ; Kuo, Chien-Hung ; Peng, Shih-Jung ; Tang, Shiue-Cheng (2015)
  • Publisher: Elsevier BV
  • Journal: EBioMedicine, volume 2, issue 2, pages 109-119 (issn: 2352-3964, eissn: 2352-3964)
  • Related identifiers: pmc: PMC4485478, doi: 10.1016/j.ebiom.2015.01.014
  • Subject: 3-D histology | Revascularization | Schwann cells | Pericytes | Medicine | NG2, neuron-glial antigen 2 | Original Article | 2-D, 2-dimensional | R | GFAP, glial fibrillary acidic protein | 3-D, 3-dimensional | Islet transplantation | Reinnervation | GFP, green fluorescence protein
    mesheuropmc: endocrine system | surgical procedures, operative | endocrine system diseases

The primary cells that participate in islet transplantation are the endocrine cells. However, in the islet microenvironment, the endocrine cells are closely associated with the neurovascular tissues consisting of the Schwann cells and pericytes, which form sheaths/barri... View more
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