Development of cultured Plasmodium falciparum blood-stage malaria cell banks for early phase in vivo clinical trial assessment of anti-malaria drugs and vaccines

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Stanisic, Danielle I; Liu, Xue Q; De, Sai Lata; Batzloff, Michael R; Forbes, Tanya; Davis, Christopher B; Sekuloski, Silvana; Chavchich, Marina; Chung, Wendy; Trenholme, Katharine; McCarthy, James S; Li, Tao; Sim, B Kim Lee; Hoffman, Stephen L; Good, Michael F;
  • Publisher: Springer Nature
  • Journal: Malaria Journal,volume 14 (issn: 1475-2875, eissn: 1475-2875)
  • Related identifiers: doi: 10.1186/s12936-015-0663-x, pmc: PMC4392471
  • Subject: Cell bank | Plasmodium falciparum | Infectious Diseases | Malaria | Good Manufacturing Practices | Methodology | Parasitology
    mesheuropmc: parasitic diseases

Background The ability to undertake controlled human malaria infection (CHMI) studies for preliminary evaluation of malaria vaccine candidates and anti-malaria drug efficacy has been limited by the need for access to sporozoite infected mosquitoes, aseptic, purified, cr... View more
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