A proteomic approach to analyse the aspirin-mediated lysine acetylome

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Tatham, Michael H.; Cole, Christian; Scullian, Paul; Wilkie, Ross; Westwood, Nicholas J.; Stark, Lesley A.; Hay, Ronald T.;
  • Publisher: The American Society for Biochemistry and Molecular Biology
  • Journal: volume 16, issue 2, pages 310-326issn: 1535-9476, eissn: 1535-9484
  • Publisher copyright policies & self-archiving
  • Identifiers: doi: 10.1074/mcp.O116.065219, pmc: PMC5294217
  • Subject: Signal transduction | QD Chemistry | Cancer therapeutics | Drug targets | Acetylation | Post-translational modifications* | Histones | QD | Chemical biology | Chemoproteomics | Technological Innovation and Resources | Aspirin | NDAS | Post-translational modifications | Substrate identification

This work is supported by Cancer Research UK Grant C434/A13067 (M.H.T & R.T.H) and Wellcome Trust Grant 098391/Z/12/7 (R.T.H.). Aspirin, or acetylsalicylic acid is widely used to control pain, inflammation and fever. Important to this function is its ability to irrev... View more