More efficient repair of DNA double-strand breaks in skeletal muscle stem cells compared to their committed progeny

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Ferdousi, Leyla Vahidi; Rocheteau, Pierre; Chayot, Romain; Montagne, Benjamin; Chaker, Zayna; Flamant, Patricia; Tajbakhsh, Shahragim; Ricchetti, Miria;
  • Publisher: HAL CCSD
  • Journal: Stem Cell Research, volume 13, issue 3, pages 492-507 (issn: 1873-5061, eissn: 1876-7753)
  • Publisher copyright policies & self-archiving
  • Identifiers: doi: 10.1016/j.scr.2014.08.005
  • Subject: [SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology | Cell Biology | Developmental Biology | Medicine(all) | Biology (General) | QH301-705.5

International audience; The loss of genome integrity in adult stem cells results in accelerated tissue aging and is possibly cancerogenic. Adult stem cells in different tissues appear to react robustly to DNA damage. We report that adult skeletal stem (satellite) cells ... View more
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