5'-Hydroxymethylcytosine Precedes Loss of CpG Methylation in Enhancers and Genes Undergoing Activation in Cardiomyocyte Maturation.

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Kranzhöfer, David K.; Gilsbach, Ralf; Grüning, Björn A.; Backofen, Rolf; Nührenberg, Thomas G.; Hein, Lutz;
(2016)
  • Publisher: Public Library of Science (PLoS)
  • Journal: PLoS ONE, volume 11, issue 11 (issn: 1932-6203, eissn: 1932-6203)
  • Publisher copyright policies & self-archiving
  • Related identifiers: pmc: PMC5112848, doi: 10.1371/journal.pone.0166575
  • Subject: Computational Biology | Research Article | Chromatin modification | Anatomy | Cardiovascular Anatomy | DNA replication | Epigenetics | Genetics | Chromosome biology | DNA | Genome Analysis | Genomics | DNA modification | Biology and life sciences | Medicine | Nucleic acids | Chromatin | Gene Ontologies | Heart | DNA methylation | Q | Mammalian Genomics | DNA transcription | R | Cell biology | Gene Regulation | Biochemistry | Science | Animal Genomics | Medicine and Health Sciences | Gene Expression

Background Cardiomyocytes undergo major changes in DNA methylation during maturation and transition to a non-proliferative state after birth. 5’-hydroxylation of methylated cytosines (5hmC) is not only involved in DNA loss of CpG methylation but is also thought to be an... View more
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