Identification of the allosteric P2X7 receptor antagonist [11C]SMW139 as a PET tracer of microglial activation

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Janssen, Bieneke; Vugts, Danielle J.; Wilkinson, Shane M.; Ory, Dieter; Chalon, Sylvie; Hoozemans, Jeroen J. M.; Schuit, Robert C.; Beaino, Wissam; Kooijman, Esther J. M.; van den Hoek, Johan; Chishty, Mansoor; Doméné, Aurélie; Van der Perren, Anke; Villa, Alessandro; Maggi, Adriana; Molenaar, Ger T.; Funke, Uta; Shevchenko, Rostislav V.; Baekelandt, Veerle; Bormans, Guy; Lammertsma, Adriaan A.; Kassiou, Michael; Windhorst, Albert D.;
(2018)

Abstract The P2X7 receptor plays a significant role in microglial activation, and as a potential drug target, the P2X7 receptor is also an interesting target in positron emission tomography. The current study aimed at the development and evaluation of a potent trace... View more
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