Avian Influenza Virus Glycoproteins Restrict Virus Replication and Spread through Human Airway Epithelium at Temperatures of the Proximal Airways

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Margaret A Scull; Laura Gillim-Ross; Celia Santos; Kim L Roberts; Elena Bordonali; Kanta Subbarao; Wendy S Barclay; Raymond J Pickles;
  • Publisher: Public Library of Science
  • Journal: PLoS Pathogens,volume 5,issue 5 (issn: 1553-7366, eissn: 1553-7374)
  • Publisher copyright policies & self-archiving
  • Related identifiers: pmc: PMC2673688, doi: 10.1371/journal.ppat.1000424
  • Subject: Infectious Diseases/Viral Infections | RC581-607 | Research Article | Virology | Microbiology | Immunologic diseases. Allergy | Infectious Diseases/Respiratory Infections | Biology (General) | QH301-705.5
    mesheuropmc: viruses | animal structures

Transmission of avian influenza viruses from bird to human is a rare event even though avian influenza viruses infect the ciliated epithelium of human airways in vitro and ex vivo. Using an in vitro model of human ciliated airway epithelium (HAE), we demonstrate that wh... View more