Transient, Consequential Increases in Extracellular Potassium Ions Accompany Channelrhodopsin2 Excitation

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J. Christopher Octeau; Mohitkumar R. Gangwani; Sushmita L. Allam; Duy Tran; Shuhan Huang; Tuan M. Hoang-Trong; Peyman Golshani; Timothy H. Rumbell; James R. Kozloski; Baljit S. Khakh;

Summary: Channelrhodopsin2 (ChR2) optogenetic excitation is widely used to study neurons, astrocytes, and circuits. Using complementary approaches in situ and in vivo, we found that ChR2 stimulation leads to significant transient elevation of extracellular potassium ion... View more
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