MHC Class II and Non-MHC Class II Genes Differentially Influence Humoral Immunity to Bacillus anthracis Lethal Factor and Protective Antigen

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Garman, Lori; Dumas, Eric K.; Kurella, Sridevi; Hunt, Jonathan J.; Crowe, Sherry R.; Nguyen, Melissa L.; Cox, Philip M.; James, Judith A.; Farris, A. Darise;
  • Publisher: Multidisciplinary Digital Publishing Institute
  • Journal: Toxins,volume 4,issue 12,pages1,451-1,467 (issn: 2072-6651, eissn: 2072-6651)
  • Publisher copyright policies & self-archiving
  • Related identifiers: doi: 10.3390/toxins4121451, pmc: PMC3528256
  • Subject: MHC class II | genetic background | Medicine | lethal factor | Article | mouse | vaccine | R | antibody response | protective antigen | <i>Bacillus anthracis</i> | Bacillus anthracis
    mesheuropmc: chemical and pharmacologic phenomena

Anthrax Lethal Toxin consists of Protective Antigen (PA) and Lethal Factor (LF), and current vaccination strategies focus on eliciting antibodies to PA. In human vaccination, the response to PA can vary greatly, and the response is often directed toward non-neutralizing... View more
  • References (41)
    41 references, page 1 of 5

    Keim, P.; Smith, K.L.; Keys, C.; Takahashi, H.; Kurata, T.; Kaufmann, A. Molecular investigation of the aum shinrikyo anthrax release in Kameido, Japan. J. Clin. Microbiol. 2001, 39, 4566-4567.

    Blendon, R.J.; Benson, J.M.; DesRoches, C.M.; Pollard, W.E.; Parvanta, C.; Herrmann, M.J. The impact of anthrax attacks on the American public. MedGenMed 2002, 4, 1.

    3. Dixon, T.C.; Meselson, M.; Guillemin, J.; Hanna, P.C. Anthrax. N. Engl. J. Med. 1999, 341, 815-826.

    4. Brossier, F.; Weber-Levy, M.; Mock, M.; Sirard, J.C. Role of toxin functional domains in anthrax pathogenesis. Infect. Immun. 2000, 68, 1781-1786.

    5. Reuveny, S.; White, M.D.; Adar, Y.Y.; Kafri, Y.; Altboum, Z.; Gozes, Y.; Kobiler, D.; Shafferman, A.; Velan, B. Search for correlates of protective immunity conferred by anthrax vaccine. Infect. Immun. 2001, 69, 2888-2893.

    6. Marcus, H.; Danieli, R.; Epstein, E.; Velan, B.; Shafferman, A.; Reuveny, S. Contribution of immunological memory to protective immunity conferred by a Bacillus anthracis protective antigen-based vaccine. Infect. Immun. 2004, 72, 3471-3477.

    7. Turnbull, P.C. Anthrax vaccines: Past, present and future. Vaccine 1991, 9, 533-539.

    8. Weiss, S.; Kobiler, D.; Levy, H.; Marcus, H.; Pass, A.; Rothschild, N.; Altboum, Z. Immunological correlates for protection against intranasal challenge of Bacillus anthracis spores conferred by a protective antigen-based vaccine in rabbits. Infect. Immun. 2006, 74, 394-398.

    9. Chitlaru, T.; Altboum, Z.; Reuveny, S.; Shafferman, A. Progress and novel strategies in vaccine development and treatment of anthrax. Immunol. Rev. 2011, 239, 221-236.

    10. Albrecht, M.T.; Li, H.; Williamson, E.D.; LeButt, C.S.; Flick-Smith, H.C.; Quinn, C.P.; Westra, H.; Galloway, D.; Mateczun, A.; Goldman, S.; et al. Human monoclonal antibodies against anthrax lethal factor and protective antigen act independently to protect against Bacillus anthracis infection and enhance endogenous immunity to anthrax. Infect. Immun. 2007, 75, 5425-5433.

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