Emergence of the Asian 1 Genotype of Dengue Virus Serotype 2 in Viet Nam: In Vivo Fitness Advantage and Lineage Replacement in South-East Asia

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Thi Ty Hang Vu; Edward C Holmes; Veasna Duong; Thien Quy Nguyen; Tinh Hien Tran; Michael Quail; Carol Churcher; Julian Parkhill; Jane Cardosa; Jeremy Farrar; Bridget Wills; Niall J Lennon; Bruce W Birren; Philippe Buchy; Matthew R Henn; Cameron P Simmons;
(2010)
  • Publisher: Public Library of Science
  • Journal: PLoS Neglected Tropical Diseases,volume 4,issue 7 (issn: 1935-2727, eissn: 1935-2735)
  • Publisher copyright policies & self-archiving
  • Related identifiers: pmc: PMC2907417, doi: 10.1371/journal.pntd.0000757
  • Subject: RC955-962 | Research Article | RA1-1270 | Public Health and Epidemiology/Infectious Diseases | Public aspects of medicine | Arctic medicine. Tropical medicine | Virology/Virus Evolution and Symbiosis
    mesheuropmc: viruses | virus diseases

A better description of the extent and structure of genetic diversity in dengue virus (DENV) in endemic settings is central to its eventual control. To this end we determined the complete coding region sequence of 187 DENV-2 genomes and 68 E genes from viruses sampled f... View more
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