The role of mRNA splicing in prostate cancer

Article English OPEN
Anna V Lapuk; Stanislav V Volik; Yuzhuo Wang; Colin C Collins;
(2014)
  • Publisher: Medknow Publications & Media Pvt Ltd
  • Journal: Asian Journal of Andrology,volume 16,issue 4,pages515-521 (issn: 1008-682X, eissn: 1745-7262)
  • Publisher copyright policies & self-archiving
  • Related identifiers: doi: 10.4103/1008-682X.127825, pmc: PMC4104073
  • Subject: REST repressor complex | Diseases of the genitourinary system. Urology | PI3K pathway | RC870-923 | prostate cancer | androgen receptor | neuroendocrine transdifferentiation | alternative splicing | alternative splicing; prostate cancer; androgen receptor; PI3K pathway; CRPC; neuroendocrine transdifferentiation; REST repressor complex | Invited Review | CRPC

Alternative splicing (AS) is a crucial step in gene expression. It is subject to intricate regulation, and its deregulation in cancer can lead to a wide array of neoplastic phenotypes. A large body of evidence implicates splice isoforms in most if not all hallmarks of c... View more
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