Hormonal Modulation of Breast Cancer Gene Expression: Implications for Intrinsic Subtyping in Premenopausal Women

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Bernhardt, Sarah M. ; Dasari, Pallave ; Walsh, David ; Townsend, Amanda R. ; Price, Timothy J. ; Ingman, Wendy V. (2016)
  • Publisher: Frontiers Media S.A.
  • Journal: Frontiers in Oncology, volume 6 (issn: 2234-943X, eissn: 2234-943X)
  • Related identifiers: pmc: PMC5107819, doi: 10.3389/fonc.2016.00241
  • Subject: hormones | Review | intrinsic subtyping | menstrual cycle | premenopausal breast cancer | Oncology | gene expression

Clinics are increasingly adopting gene-expression profiling to diagnose breast cancer subtype, providing an intrinsic, molecular portrait of the tumor. For example, the PAM50-based Prosigna test quantifies expression of 50 key genes to classify breast cancer subtype, an... View more
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