Photoactivation of MDM2 Inhibitors: Controlling Protein-Protein Interaction with Light

Article English OPEN
Hansen, Mickel J.; Feringa, Femke M.; Kobauri, Piermichele; Szymanski, Wiktor; Medema, René H.; Feringa, Ben L.;
(2018)
  • Publisher: American Chemical Society
  • Journal: Journal of the American Chemical Society,volume 140,issue 41,pages13,136-13,141 (issn: 0002-7863, eissn: 1520-5126)
  • Publisher copyright policies & self-archiving
  • Related identifiers: doi: 10.1021/jacs.8b04870, pmc: PMC6194649
  • Subject: PHOTOREMOVABLE PROTECTING GROUPS | THERAPIES | CYCLOADDITION | P53 PATHWAY | To be checked by Faculty | Communication | ACTIVATION | PRACTICAL SYNTHESIS | STABILITY | PHOTOPHARMACOLOGY

Selectivity remains a major challenge in anticancer therapy, which potentially can be overcome by local activation of a cytotoxic drug. Such triggered activation can be obtained through modification of a drug with a photoremovable protecting group (PPG), and subsequent ... View more
Share - Bookmark