publication . Article . 2014

GABA level, gamma oscillation, and working memory performance in schizophrenia

Chen, Chi-Ming A.; Stanford, Arielle D.; Mao, Xiangling; Abi-Dargham, Anissa; Shungu, Dikoma C.; Lisanby, Sarah H.; Schroeder, Charles E.; Kegeles, Lawrence S.;
Open Access English
  • Published: 01 Mar 2014 Journal: NeuroImage : Clinical, volume 4, pages 531-539 (issn: 2213-1582, eissn: 2213-1582, Copyright policy)
  • Publisher: Elsevier
Abstract
A relationship between working memory impairment, disordered neuronal oscillations, and abnormal prefrontal GABA function has been hypothesized in schizophrenia; however, in vivo GABA measurements and gamma band neural synchrony have not yet been compared in schizophrenia. This case–control pilot study (N = 24) compared baseline and working memory task-induced neuronal oscillations acquired with high-density electroencephalograms (EEGs) to GABA levels measured in vivo with magnetic resonance spectroscopy. Working memory performance, baseline GABA level in the left dorsolateral prefrontal cortex (DLPFC), and measures of gamma oscillations from EEGs at baseline an...
Subjects
mesheuropmc: nervous system
free text keywords: R858-859.7, Computer applications to medicine. Medical informatics, Neurology. Diseases of the nervous system, Working memory, Gamma oscillation, RC346-429, Magnetic resonance spectroscopy, GABA, Schizophrenia, Dorsolateral prefrontal cortex, Article
Funded by
NIH| Negative Symptoms of Schizophrenia: From Phenomenology to Targeted Treatment
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 7K23MH076976-06
  • Funding stream: NATIONAL INSTITUTE OF MENTAL HEALTH
,
NIH| Novel MRS Neurotechnology for Imaging GABA &Glutamate Function in Schizophrenia
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5R01MH075895-03
  • Funding stream: NATIONAL INSTITUTE OF MENTAL HEALTH
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publication . Article . 2014

GABA level, gamma oscillation, and working memory performance in schizophrenia

Chen, Chi-Ming A.; Stanford, Arielle D.; Mao, Xiangling; Abi-Dargham, Anissa; Shungu, Dikoma C.; Lisanby, Sarah H.; Schroeder, Charles E.; Kegeles, Lawrence S.;