Growth of Limb Muscle is Dependent on Skeletal-Derived Indian Hedgehog

Article, Other literature type English OPEN
Bren-Mattison, Yvette ; Hausburg, Melissa ; Olwin, Bradley B. (2011)
  • Publisher: Elsevier BV
  • Journal: Developmental Biology, volume 356, issue 2, pages 486-495 (issn: 0012-1606)
  • Related identifiers: doi: 10.1016/j.ydbio.2011.06.002, pmc: PMC3322465
  • Subject: Molecular Biology | Cell Biology | Developmental Biology | Article
    mesheuropmc: body regions | embryonic structures | animal structures

During embryogenesis, muscle and bone develop in close temporal and spatial proximity. We show that Indian Hedgehog, a bone-derived signaling molecule, participates in growth of skeletal muscle. In Ihh−/− embryos, skeletal muscle development appears abnormal at embryoni... View more
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